Cardiovascular effects of BRX-005 comparison to bimoclomol

Ágnes Körtvély, Gyula Szigeti, Rudolf Gesztelyi, Judit Zsuga, Tamás Bányász, János Magyar, Péter Szigligeti, László Kovács, Andrea Jednákovits, A. József Szentmiklósi, Péter P. Nánási

Research output: Article

1 Citation (Scopus)

Abstract

Concentration-dependent effects of BRX-005, the novel heat shock protein coinducer, cardioprotective and vasoprotective agent, on intracellular calcium transients and contractility were studied in Langendorff-perfused guinea pig hearts loaded with the fluorescent calcium indicator dye Fura-2. BRX-005 increased peak left ventricular pressure, the rate of force development and relaxation significantly in a concentration-dependent manner. The amplitude of [Ca2+](i) transients was left unaltered by the drug. In contrast to BRX-005, bimoclomol increased both contractility and the amplitude of [Ca2+](i) transients. In canine ventricular cardiomyocytes high concentrations of BRX-005 had no effect on depolarization, whereas bimoclomol suppressed action potential upstroke markedly. In guinea pig pulmonary artery preparations precontracted with phenylephrine, BRX-005 induced concentration- dependent relaxation. This effect of BRX-005 was independent of the integrity of endothelium indicating that vasorelaxant effect of the drug develops directly on vascular smooth muscle. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)1783-1789
Number of pages7
JournalLife Sciences
Volume67
Issue number14
DOIs
Publication statusPublished - aug. 25 2000

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Körtvély, Á., Szigeti, G., Gesztelyi, R., Zsuga, J., Bányász, T., Magyar, J., Szigligeti, P., Kovács, L., Jednákovits, A., Szentmiklósi, A. J., & Nánási, P. P. (2000). Cardiovascular effects of BRX-005 comparison to bimoclomol. Life Sciences, 67(14), 1783-1789. https://doi.org/10.1016/S0024-3205(00)00755-4