Cardiovascularis és humorális adaptáció passzív orthostasis során.

Z. László, A. Rössler, G. H. Hinghofer-Szalkay

Research output: Article

Abstract

The aim of our study was to quantitate, in the same test subjects, hormonal, thoracic bioimpedance, blood composition, and hemodynamic dose-responses during different angles of passive orthostatic loading (head-up tilt, HUT) ranging from 12 degrees to 70 degrees. Measurements were performed with 20 min supine (pre-HUT), 30 min upright (HUT-12 degrees, HUT-30 degrees, HUT-53 degrees, or HUT-70 degrees), and 20 min supine (post-HUT); or supine only (HUT-0 degree, rest control). Norepinephrine increased above rest control by 19, 44, 80 and 102%; epinephrine 30, 41, 64, and 68%; aldosterone 29, 62, 139, and 165%; plasma renin activity n. s., 41, 91, and 89%; vasopressin n. s., 27, 47, and 59%; thoracic bioimpedance n. s., 8, 13, and 16%; heart rate n. s., 5, 26, and 45%, and mean arterial pressure n. s., 5, 7, and 10%; respectively, at min 27 of HUT-12 degrees, -30 degrees, -53 degrees, and -70 degrees. Pulse pressure narrowed with HUT-53 degrees and -70 degrees by 4 and 10%. Hematocrit increased 0.2, 1.7, 6.3, and 7.2%, respectively. Blood density increased by 2.3 and 3.0 g/l, plasma density by 1.7 and 1.8 g/l with HUT-53 degrees and -70 degrees. After finishing HUT, heart rate fell to values which stayed below pre-HUT, and also below rest control levels for > or = 5 min ("post-orthostatic bradycardia") even after the lowest orthostatic load (HUT-12 degrees). Thoracic bioimpedance and arterial blood pressure stayed increased after finishing HUT-30 degrees, -53 degrees, and -70 degrees. In summary, passive orthostasis of different degree produces specific dose-responses of different magnitude within endocrine, blood concentration, thoracic bioimpedance, and hemodynamic variables. Heart rate is depressed even after HUT-12 degrees, while arterial blood pressure and thoracic bioimpedance exceed pre-stimulus levels after HUT of higher degree, indicating altered cardiovascular state after passive orthostasis.

Translated title of the contributionCardiovascular and humoral adaptation with passive orthostasis in men
Original languageHungarian
Pages (from-to)887-893
Number of pages7
JournalOrvosi hetilap
Volume142
Issue number17
Publication statusPublished - ápr. 29 2001

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    László, Z., Rössler, A., & Hinghofer-Szalkay, G. H. (2001). Cardiovascularis és humorális adaptáció passzív orthostasis során. Orvosi hetilap, 142(17), 887-893.