Carbonate-radical-anions, and not hydroxyl radicals, are the products of the Fenton reaction in neutral solutions containing bicarbonate

E. Illés, Amir Mizrahi, Vered Marks, Dan Meyerstein

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Abstract

The Fenton reaction, Fe(H2O)6 2+ + H2O2 → Oxidizing product, is of major importance in biology as the major cause of oxidative stress, and in advanced oxidation processes. It is commonly assumed that ·OH is the product of the Fenton reaction. The results presented herein point out that ·OH is indeed the oxidizing product in acidic solutions for [Fe(H2O)6 2+] > [H2O2]; FeIV aq is the active oxidizing product in neutral solutions; in slightly acidic solutions for [H2O2] > [Fe(H2O)6 2+] a mixture of ·OH and FeIV aq is formed. However CO3·- is the active oxidizing product in neutral solutions containing HCO3 - even at low concentrations, i.e. under physiological conditions. The implications to our understanding of the origins of oxidative stress and of catalytic oxidations in advanced oxidation processes are discussed.

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???journalAssociation???Free Radical Biology and Medicine
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???publicationStatus???Published - febr. 1 2019

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Carbonates
Bicarbonates
Hydroxyl Radical
Anions
Oxidative stress
Oxidative Stress
Oxidation
Catalytic oxidation

Keywords

    ASJC Scopus subject areas

    • Biochemistry
    • Physiology (medical)

    Cite this

    Carbonate-radical-anions, and not hydroxyl radicals, are the products of the Fenton reaction in neutral solutions containing bicarbonate. / Illés, E.; Mizrahi, Amir; Marks, Vered; Meyerstein, Dan.

    ???in???: Free Radical Biology and Medicine, ???journal.volume??? 131, 01.02.2019, ???pages??? 1-6.

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    abstract = "The Fenton reaction, Fe(H2O)6 2+ + H2O2 → Oxidizing product, is of major importance in biology as the major cause of oxidative stress, and in advanced oxidation processes. It is commonly assumed that ·OH is the product of the Fenton reaction. The results presented herein point out that ·OH is indeed the oxidizing product in acidic solutions for [Fe(H2O)6 2+] > [H2O2]; FeIV aq is the active oxidizing product in neutral solutions; in slightly acidic solutions for [H2O2] > [Fe(H2O)6 2+] a mixture of ·OH and FeIV aq is formed. However CO3·- is the active oxidizing product in neutral solutions containing HCO3 - even at low concentrations, i.e. under physiological conditions. The implications to our understanding of the origins of oxidative stress and of catalytic oxidations in advanced oxidation processes are discussed.",
    keywords = "Bicarbonate, Carbonate-radical-anion, Fenton reaction, Iron, Radicals",
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    AU - Illés, E.

    AU - Mizrahi, Amir

    AU - Marks, Vered

    AU - Meyerstein, Dan

    PY - 2019/2/1

    Y1 - 2019/2/1

    N2 - The Fenton reaction, Fe(H2O)6 2+ + H2O2 → Oxidizing product, is of major importance in biology as the major cause of oxidative stress, and in advanced oxidation processes. It is commonly assumed that ·OH is the product of the Fenton reaction. The results presented herein point out that ·OH is indeed the oxidizing product in acidic solutions for [Fe(H2O)6 2+] > [H2O2]; FeIV aq is the active oxidizing product in neutral solutions; in slightly acidic solutions for [H2O2] > [Fe(H2O)6 2+] a mixture of ·OH and FeIV aq is formed. However CO3·- is the active oxidizing product in neutral solutions containing HCO3 - even at low concentrations, i.e. under physiological conditions. The implications to our understanding of the origins of oxidative stress and of catalytic oxidations in advanced oxidation processes are discussed.

    AB - The Fenton reaction, Fe(H2O)6 2+ + H2O2 → Oxidizing product, is of major importance in biology as the major cause of oxidative stress, and in advanced oxidation processes. It is commonly assumed that ·OH is the product of the Fenton reaction. The results presented herein point out that ·OH is indeed the oxidizing product in acidic solutions for [Fe(H2O)6 2+] > [H2O2]; FeIV aq is the active oxidizing product in neutral solutions; in slightly acidic solutions for [H2O2] > [Fe(H2O)6 2+] a mixture of ·OH and FeIV aq is formed. However CO3·- is the active oxidizing product in neutral solutions containing HCO3 - even at low concentrations, i.e. under physiological conditions. The implications to our understanding of the origins of oxidative stress and of catalytic oxidations in advanced oxidation processes are discussed.

    KW - Bicarbonate

    KW - Carbonate-radical-anion

    KW - Fenton reaction

    KW - Iron

    KW - Radicals

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