Dupuytren's disease is a hand deformity in which the connective tissue of the subcutaneous palmar fascia contracts and toughens over time, eventually forming a thick cord that pulls one or more fingers into a bent position. The reason why this tissue becomes thickened is not precisely described yet. The aim of this study was to characterize the altered metabolism in palmar connective tissue that promotes disease progression. Normal and diseased palmar fascial complexes were acquired during live surgery and the investigation was performed in a relatively short period of time compared to the earlier reports. Similar sample environment was provided for the normal and degenerative samples. The thermal properties of samples were determined by differential scanning calorimetry. Before the examination all water from the surface was removed. Samples were heated from 0 to 80 C. The heating rate was 0.3 K min-1. Conventional aluminum alloy vessels were used with 40 μL sample volume. All samples showed a clear denaturation peak on the calorimetric curve. Change in the enthalpy was observed in normal palmar aponeurosis at -1431.85 kJ kg -1 (SD = 371.58). In the affected sample -1508.70 kJ kg-1 (SD = 245.66) was measured. Our results showed clear evidence that complex deviations from the normal matrix composition during the late stage of degeneration correlated significantly with changes in thermal properties.
ASJC Scopus subject areas
- Condensed Matter Physics
- Physical and Theoretical Chemistry