Enantioselective solubility of rac-norgestrel was found in the presence of γ-cyclodextrin or hydroxypropyl-γ-cyclodextrin. In both cases the efficacious enantiomer was dissolved in greater extent. Calculating the molar absorptivity and molar ellipticity spectra of the γ- and hydroxypropyl-γ-cyclodextrin aqueous complexes, a simple and rapid direct circular dichroism (CD) spectrometric method was obtained for the determination of the enantiomer ratio in aqueous solutions.
|Number of pages||4|
|Journal||Journal of Inclusion Phenomena and Macrocyclic Chemistry|
|Publication status||Published - ápr. 1 2007|
ASJC Scopus subject areas
- Food Science
- Condensed Matter Physics