Brenner chose C. elegans as his experimental animal with the objective of understanding the genetic program of development and the organization of a complex organism. C. elegans possesses a limited number of cells, a good reproductive capacity, rapid development, and suitability for genetic analysis and gene manipulations.13'6 The first articles by Brenner1'6 and Sulston and Brenner2 pioneered this program, and about 60 laboratories throughout the world are currently conducting research on C. elegans, The unique feature of Brenner's concepts in C. elegans research is that almost all complex phenomena (e.g., timing of cell lineages, dauer formation and recovery, aging, behavior, and drug resistance) have been described in genetic and molecular terms. More than 75% of the nematode genome has been physically mapped and is kept in DNA libraries; the whole cell lineage chart has been reconstructed and described at phenological and genetic levels.3.
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)