C1q autoantibodies in HIV infection: Correlation to elevated levels of autoantibodies against 60-kDa heat-shock proteins

Z. Prohászka, M. R. Daha, C. Süsal, V. Daniel, J. Szlávik, D. Bánhegyi, K. Nagy, V. Várkonyi, A. Horváth, E. Ujhelyi, F. D. Tóth, K. Uray, F. Hudecz, G. Füst

Research output: Article

24 Citations (Scopus)

Abstract

Antibodies to solid phase C1q (C1qAb) were determined in 295 serum samples from 132 HIV-infected subjects and in sera from 140 HIV-seronegative healthy individuals as control. An ELISA method applied for the determination of C1qAb in other diseases was used. In part of these sera, other autoantibodies (antibodies reacting with 60-kDa human heat shock protein (hsp60) or mycobacterial hsp65; IgA and IgG class antibodies against the Fab and F(ab')2 moieties of IgG) as well as complement-mediated antibody- dependent enhancement/neutralization (C'-ADE) were also determined. Increased amount of C1qAb was found in HIV-infected subjects as compared with HIV- seronegative controls (P = 0.0138). In 17 of 132 (13.0%) seropositive individuals but only in 7/140 (5.0%) samples from the controls, the amount of C1qAb exceeded the upper limit (95th percentile) of the normal values (P = 0.031). The amount of C1qAb significantly decreased during a follow-up period of 65 months. C1qAb levels were found to strongly correlate to hsp60/65 autoantibodies but did not correlate or only weakly correlated to the amount of anti-Fab or anti-F(ab')2 autoantibodies measured in the same serum samples. Anti-C1q antibodies recognized the solid phase hsp60/65. Three predicted epitope regions of M. paratuberculosis hsp65 were able to bind efficiently C1q antibodies. An inverse correlation was found between C1qAb and C'-ADE, neutralization was more frequent in the sera with detectable C1qAb, whereas sera without C1qAb more likely enhanced HIV infection in vitro.

Original languageEnglish
Pages (from-to)247-255
Number of pages9
JournalClinical Immunology
Volume90
Issue number2
DOIs
Publication statusPublished - febr. 1999

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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