Bulk and surface sensitivity of a resonant waveguide grating imager

Norbert Orgovan, Boglarka Kovacs, Eniko Farkas, Bálint Szabó, Natalya Zaytseva, Ye Fang, Robert Horvath

Research output: Article

30 Citations (Scopus)

Abstract

We report the assessment of the sensitivity of a microplate-compatible resonant waveguide grating imager. The sensitivity to bulk refractive index changes was determined using a serial dilution of glycerol solution with the help of a refractometer. The surface sensitivity was examined using layer-by-layer polyelectrolyte films in conjunction with optical waveguide lightmode spectroscopy and characterized by the binding of acetazolamide to immobilized carbonic anhydrase under microfluidics. The results suggest that the imager has a limit of detection down to 2.2 × 10-6 for refractive index change and 0.078 ng/cm2 for the adsorbed mass.

Original languageEnglish
Article number083506
JournalApplied Physics Letters
Volume104
Issue number8
DOIs
Publication statusPublished - jan. 1 2014

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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