Branched polymeric polypeptides with poly[Lys]

Research output: Chapter

Abstract

This chapter is to outline the design, synthesis, chemical and functional characterization of a set of structurally related branched polymeric polypeptides with poly[Lys] backbone. It has been documented that the composition and amino acid sequence of the branch could markedly determine the physico-chemical characteristics including solution conformation, the interaction phospholipid mono- or bilayers as well as the biological properties, like cytotoxicity, blood clearance, biodistribution, immunoreactivity of the compound and even related bioconjugates with chemotherapeutic agent, peptide epitope or reporter entity. The synthesis, structural and functional characterization of conjugates, in which (i) various antitumour, antiparasitic compounds (e.g. daunomycin, methotrexate, GnRH analogue), (ii) imaging agents (e.g. radionuclides, fluorophores) or (iii) B- and/or T-cell epitope peptides from viral (e.g. Herpes simplex virus), bacterial (e.g. M. tuberculosis) and various disease (e.g. tumour, Alzheimer disease) related proteins are attached covalently to selected poly[Lys] branched polymeric polypeptides are discussed.

Original languageEnglish
Title of host publicationAmino Acids, Peptides and Proteins
Subtitle of host publicationVolume 43
EditorsHudecz Ferenc, Maxim Ryadnov
PublisherRoyal Society of Chemistry
Pages44-90
Number of pages47
ISBN (Electronic)9781788013673
DOIs
Publication statusPublished - jan. 1 2019

Publication series

NameAmino Acids, Peptides and Proteins
Volume43
ISSN (Print)1361-5904

Fingerprint

Peptides
B-Lymphocyte Epitopes
Antiparasitic Agents
Bacteriophages
Daunorubicin
T-Lymphocyte Epitopes
Fluorophores
Simplexvirus
Cytotoxicity
Gonadotropin-Releasing Hormone
Methotrexate
Radioisotopes
Conformations
Tumors
Epitopes
Amino Acid Sequence
Monolayers
Phospholipids
Alzheimer Disease
Tuberculosis

ASJC Scopus subject areas

  • Biochemistry

Cite this

Hudecz, F. (2019). Branched polymeric polypeptides with poly[Lys]. In H. Ferenc, & M. Ryadnov (Eds.), Amino Acids, Peptides and Proteins: Volume 43 (pp. 44-90). (Amino Acids, Peptides and Proteins; Vol. 43). Royal Society of Chemistry. https://doi.org/10.1039/9781788013857-00044

Branched polymeric polypeptides with poly[Lys]. / Hudecz, F.

Amino Acids, Peptides and Proteins: Volume 43. ed. / Hudecz Ferenc; Maxim Ryadnov. Royal Society of Chemistry, 2019. p. 44-90 (Amino Acids, Peptides and Proteins; Vol. 43).

Research output: Chapter

Hudecz, F 2019, Branched polymeric polypeptides with poly[Lys]. in H Ferenc & M Ryadnov (eds), Amino Acids, Peptides and Proteins: Volume 43. Amino Acids, Peptides and Proteins, vol. 43, Royal Society of Chemistry, pp. 44-90. https://doi.org/10.1039/9781788013857-00044
Hudecz F. Branched polymeric polypeptides with poly[Lys]. In Ferenc H, Ryadnov M, editors, Amino Acids, Peptides and Proteins: Volume 43. Royal Society of Chemistry. 2019. p. 44-90. (Amino Acids, Peptides and Proteins). https://doi.org/10.1039/9781788013857-00044
Hudecz, F. / Branched polymeric polypeptides with poly[Lys]. Amino Acids, Peptides and Proteins: Volume 43. editor / Hudecz Ferenc ; Maxim Ryadnov. Royal Society of Chemistry, 2019. pp. 44-90 (Amino Acids, Peptides and Proteins).
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