Brain enkephalin distribution is unaltered by hypophysectomy

Ronald M. Kobayashi, Miklos Palkovits, Richard J. Miller, Kwen Jen Chang, Pedro Cuatrecasas

Research output: Article

47 Citations (Scopus)


Methionine (met) and leucine (leu)-enkephalin were measured by radioimmunoassay in 16 brain regions removed by microdissection in intact rats. In hypophysectomized rats the regional concentrations of the enkephalins was not altered. Brain enkephalins do not appear to be derived from pituitary endorphins.

Original languageEnglish
Pages (from-to)527-530
Number of pages4
JournalLife Sciences
Issue number6
Publication statusPublished - febr. 1978

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Kobayashi, R. M., Palkovits, M., Miller, R. J., Chang, K. J., & Cuatrecasas, P. (1978). Brain enkephalin distribution is unaltered by hypophysectomy. Life Sciences, 22(6), 527-530.