Bradykinin and angiotensin II inhibit neurotransmission in rabbit ear artery by releasing prostanoids

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9 Citations (Scopus)

Abstract

In isolated, perfused rabbit ear artery bradykinin, like [Met5enkephalin and angiotensin II, inhibited neurogenic constrictions in concentrations lower than 10-8M without affecting the responses to exogenous norepinephrine. The IC50 value of bradykinin was 1.95 × 10-10 M. The inhibitory action of bradykinin and angiotensin II but not of [Met5enkephalin was reduced or even reversed by indomethacin pretreatment, suggesting that endogenous prostanoids are involved.

Original languageEnglish
Pages (from-to)93-95
Number of pages3
JournalEuropean Journal of Pharmacology
Volume198
Issue number1
DOIs
Publication statusPublished - máj. 30 1991

Fingerprint

Bradykinin
Synaptic Transmission
Angiotensin II
Prostaglandins
Ear
Arteries
Rabbits
Constriction
Indomethacin
Inhibitory Concentration 50
Norepinephrine

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

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abstract = "In isolated, perfused rabbit ear artery bradykinin, like [Met5enkephalin and angiotensin II, inhibited neurogenic constrictions in concentrations lower than 10-8M without affecting the responses to exogenous norepinephrine. The IC50 value of bradykinin was 1.95 × 10-10 M. The inhibitory action of bradykinin and angiotensin II but not of [Met5enkephalin was reduced or even reversed by indomethacin pretreatment, suggesting that endogenous prostanoids are involved.",
keywords = "Angiotensin II, Bradykinin, Ear artery (rabbit), Indomethacin, [Met]enkephalin",
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T1 - Bradykinin and angiotensin II inhibit neurotransmission in rabbit ear artery by releasing prostanoids

AU - Rónai, A.

PY - 1991/5/30

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AB - In isolated, perfused rabbit ear artery bradykinin, like [Met5enkephalin and angiotensin II, inhibited neurogenic constrictions in concentrations lower than 10-8M without affecting the responses to exogenous norepinephrine. The IC50 value of bradykinin was 1.95 × 10-10 M. The inhibitory action of bradykinin and angiotensin II but not of [Met5enkephalin was reduced or even reversed by indomethacin pretreatment, suggesting that endogenous prostanoids are involved.

KW - Angiotensin II

KW - Bradykinin

KW - Ear artery (rabbit)

KW - Indomethacin

KW - [Met]enkephalin

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