Bone marrow transplantation in non-malignant disorders

G. Krivan, L. Timar, V. Goda, M. Reti, P. Remenyi, T. Masszi

Research output: Article

6 Citations (Scopus)

Abstract

From January 1992 to December 1997, 21 consecutive patients (14 SAA, 3 SCID, 1 Fanconi anemia, 1 Diamond-Blackfan anemia, 1 mucolipidosis and 1 mucopolysaccharidosis type I.) were transplanted (16 HLA-id. family, 2 MUD and 3 haploidentical family donors) in a single center. The median follow up period is 41 months (range 7-76). The probability of 3.5 year overall disease free survival is 14/21 (67%), the transplant related mortality is 4/21 (19%). All the SCID patients are alive and disease free. 3 SAA patients had signs of fungal infection prior to transplant. They died in spite of intensive antifungal treatment resulting reduced DFS for SAA to 71%. Two patients with lysosomal storage disorders (mucolipidosis and MPS I.) rejected the haploidentical T-cell depleted graft 1 and 11 months after transplant, respectively. In 2 cases non-engraftment occured, both patients were retransplanted succesfully.

Original languageEnglish
JournalBone Marrow Transplantation
Volume22
Issue numberSUPPL. 4
Publication statusPublished - 1998

Fingerprint

Bone Marrow Transplantation
Mucolipidoses
Mucopolysaccharidosis I
Transplants
Fanconi Anemia
Mycoses
Disease-Free Survival
Tissue Donors
T-Lymphocytes
Mortality
Therapeutics

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Krivan, G., Timar, L., Goda, V., Reti, M., Remenyi, P., & Masszi, T. (1998). Bone marrow transplantation in non-malignant disorders. Bone Marrow Transplantation, 22(SUPPL. 4).

Bone marrow transplantation in non-malignant disorders. / Krivan, G.; Timar, L.; Goda, V.; Reti, M.; Remenyi, P.; Masszi, T.

In: Bone Marrow Transplantation, Vol. 22, No. SUPPL. 4, 1998.

Research output: Article

Krivan, G, Timar, L, Goda, V, Reti, M, Remenyi, P & Masszi, T 1998, 'Bone marrow transplantation in non-malignant disorders', Bone Marrow Transplantation, vol. 22, no. SUPPL. 4.
Krivan G, Timar L, Goda V, Reti M, Remenyi P, Masszi T. Bone marrow transplantation in non-malignant disorders. Bone Marrow Transplantation. 1998;22(SUPPL. 4).
Krivan, G. ; Timar, L. ; Goda, V. ; Reti, M. ; Remenyi, P. ; Masszi, T. / Bone marrow transplantation in non-malignant disorders. In: Bone Marrow Transplantation. 1998 ; Vol. 22, No. SUPPL. 4.
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