Bone disorders in experimentally induced liver disease in growing rats

Viktória Ferencz, C. Horváth, Béla Kári, János Gaál, Szilvia Mészáros, Zsuzsanna Wolf, Dalma Hegedus, Andrea Horváth, Anikó Folhoffer, F. Szalay

Research output: Article

3 Citations (Scopus)

Abstract

Aim: To investigate the change of bone parameters in a new model of experimentally induced liver cirrhosis and hepatocellular carcinoma (HCC) in growing rats. Methods: Fischer-344 rats (n = 55) were used. Carbon tetrachloride (CCl4), phenobarbital (PB), and a single diethylnitrosamine (DEN) injection were used. Animals were killed at wk 8 and 16. Bone mineral content, femoral length, cortical index (quotient of cortical thickness and whole diameter) and ultimate bending load (Fmax) of the femora were determined. The results in animals treated with DEN+PB+CCl4 (DPC, n = 21) were compared to those in untreated animals (UNT, n = 14) and in control group treated only with DEN+PB (DP, n = 20). Results: Fatty liver and cirrhosis developed in each DPC-treated rat at wk 8 and HCC was presented at wk 16. No skeletal changes were found in this group at wk 8, but each parameter was lower (Pmax values were higher (P

Original languageEnglish
Pages (from-to)7169-7173
Number of pages5
JournalWorld Journal of Gastroenterology
Volume11
Issue number45
Publication statusPublished - dec. 7 2005

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Diethylnitrosamine
Phenobarbital
Liver Diseases
Bone and Bones
Liver Cirrhosis
Hepatocellular Carcinoma
Carbon Tetrachloride
Inbred F344 Rats
Fatty Liver
Thigh
Bone Density
Femur
Control Groups
Injections

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Ferencz, V., Horváth, C., Kári, B., Gaál, J., Mészáros, S., Wolf, Z., ... Szalay, F. (2005). Bone disorders in experimentally induced liver disease in growing rats. World Journal of Gastroenterology, 11(45), 7169-7173.

Bone disorders in experimentally induced liver disease in growing rats. / Ferencz, Viktória; Horváth, C.; Kári, Béla; Gaál, János; Mészáros, Szilvia; Wolf, Zsuzsanna; Hegedus, Dalma; Horváth, Andrea; Folhoffer, Anikó; Szalay, F.

In: World Journal of Gastroenterology, Vol. 11, No. 45, 07.12.2005, p. 7169-7173.

Research output: Article

Ferencz, V, Horváth, C, Kári, B, Gaál, J, Mészáros, S, Wolf, Z, Hegedus, D, Horváth, A, Folhoffer, A & Szalay, F 2005, 'Bone disorders in experimentally induced liver disease in growing rats', World Journal of Gastroenterology, vol. 11, no. 45, pp. 7169-7173.
Ferencz V, Horváth C, Kári B, Gaál J, Mészáros S, Wolf Z et al. Bone disorders in experimentally induced liver disease in growing rats. World Journal of Gastroenterology. 2005 dec. 7;11(45):7169-7173.
Ferencz, Viktória ; Horváth, C. ; Kári, Béla ; Gaál, János ; Mészáros, Szilvia ; Wolf, Zsuzsanna ; Hegedus, Dalma ; Horváth, Andrea ; Folhoffer, Anikó ; Szalay, F. / Bone disorders in experimentally induced liver disease in growing rats. In: World Journal of Gastroenterology. 2005 ; Vol. 11, No. 45. pp. 7169-7173.
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