Blood cell changes in complement activation-related pseudoallergy

Zsófia Patkó, J. Szebeni

Research output: Article

5 Citations (Scopus)

Abstract

The characteristic physiological changes in complement (C) activation-related pseudoallergy (CARPA) include thrombocytopenia, leukocytosis and leukopenia with or without compensatory leukocytosis. In the background of these phenomena it is known that anaphylatoxins, the triggers of CARPA, can activate white blood cells (WBCs) and platelets, and that this activation can lead to the binding of these cells to each other and also to capillary endothelial cells, entailing microthrombus formation and circulatory blockage mainly in the pulmonary and coronary microcirculation. These changes are key contributors to the hemodynamic alterations in CARPA, and can lead to anaphylactic shock. The goal of this review was to catalogue the blood cell changes in man and different animals undergoing CARPA and focus on some details of the molecular and cellular interactions among anaphylatoxins, other C activation byproducts, platelets, WBCs (mainly monocytes), macrophages and endothelial cells and these cells' secretory products during CARPA. By discussing the inhibitors of different steps of the complex interplay between reaction mediators and cell surface receptors, the review might help in identifying possible novel drugs candidates against CARPA.

Original languageEnglish
Pages (from-to)233-244
Number of pages12
JournalEuropean Journal of Nanomedicine
Volume7
Issue number3
DOIs
Publication statusPublished - jún. 1 2015

Fingerprint

Anaphylatoxins
blood cells
Complement Activation
Leukocytosis
Platelet Activation
complement
Blood Cells
Leukocytes
Blood
Endothelial Cells
Chemical activation
Cells
activation
Leukopenia
Cell Surface Receptors
Anaphylaxis
Microcirculation
Thrombocytopenia
Monocytes
Blood Platelets

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Physical and Theoretical Chemistry
  • Biomedical Engineering

Cite this

Blood cell changes in complement activation-related pseudoallergy. / Patkó, Zsófia; Szebeni, J.

In: European Journal of Nanomedicine, Vol. 7, No. 3, 01.06.2015, p. 233-244.

Research output: Article

@article{bc9d7e86cff74830b26d4b2ac2fd2120,
title = "Blood cell changes in complement activation-related pseudoallergy",
abstract = "The characteristic physiological changes in complement (C) activation-related pseudoallergy (CARPA) include thrombocytopenia, leukocytosis and leukopenia with or without compensatory leukocytosis. In the background of these phenomena it is known that anaphylatoxins, the triggers of CARPA, can activate white blood cells (WBCs) and platelets, and that this activation can lead to the binding of these cells to each other and also to capillary endothelial cells, entailing microthrombus formation and circulatory blockage mainly in the pulmonary and coronary microcirculation. These changes are key contributors to the hemodynamic alterations in CARPA, and can lead to anaphylactic shock. The goal of this review was to catalogue the blood cell changes in man and different animals undergoing CARPA and focus on some details of the molecular and cellular interactions among anaphylatoxins, other C activation byproducts, platelets, WBCs (mainly monocytes), macrophages and endothelial cells and these cells' secretory products during CARPA. By discussing the inhibitors of different steps of the complex interplay between reaction mediators and cell surface receptors, the review might help in identifying possible novel drugs candidates against CARPA.",
keywords = "anaphylatoxins, animal models, hypersensitivity reactions, platelets, pseudoallergy, white blood cells",
author = "Zs{\'o}fia Patk{\'o} and J. Szebeni",
year = "2015",
month = "6",
day = "1",
doi = "10.1515/ejnm-2015-0021",
language = "English",
volume = "7",
pages = "233--244",
journal = "European Journal of Nanomedicine",
issn = "1662-5986",
publisher = "Walter de Gruyter GmbH",
number = "3",

}

TY - JOUR

T1 - Blood cell changes in complement activation-related pseudoallergy

AU - Patkó, Zsófia

AU - Szebeni, J.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - The characteristic physiological changes in complement (C) activation-related pseudoallergy (CARPA) include thrombocytopenia, leukocytosis and leukopenia with or without compensatory leukocytosis. In the background of these phenomena it is known that anaphylatoxins, the triggers of CARPA, can activate white blood cells (WBCs) and platelets, and that this activation can lead to the binding of these cells to each other and also to capillary endothelial cells, entailing microthrombus formation and circulatory blockage mainly in the pulmonary and coronary microcirculation. These changes are key contributors to the hemodynamic alterations in CARPA, and can lead to anaphylactic shock. The goal of this review was to catalogue the blood cell changes in man and different animals undergoing CARPA and focus on some details of the molecular and cellular interactions among anaphylatoxins, other C activation byproducts, platelets, WBCs (mainly monocytes), macrophages and endothelial cells and these cells' secretory products during CARPA. By discussing the inhibitors of different steps of the complex interplay between reaction mediators and cell surface receptors, the review might help in identifying possible novel drugs candidates against CARPA.

AB - The characteristic physiological changes in complement (C) activation-related pseudoallergy (CARPA) include thrombocytopenia, leukocytosis and leukopenia with or without compensatory leukocytosis. In the background of these phenomena it is known that anaphylatoxins, the triggers of CARPA, can activate white blood cells (WBCs) and platelets, and that this activation can lead to the binding of these cells to each other and also to capillary endothelial cells, entailing microthrombus formation and circulatory blockage mainly in the pulmonary and coronary microcirculation. These changes are key contributors to the hemodynamic alterations in CARPA, and can lead to anaphylactic shock. The goal of this review was to catalogue the blood cell changes in man and different animals undergoing CARPA and focus on some details of the molecular and cellular interactions among anaphylatoxins, other C activation byproducts, platelets, WBCs (mainly monocytes), macrophages and endothelial cells and these cells' secretory products during CARPA. By discussing the inhibitors of different steps of the complex interplay between reaction mediators and cell surface receptors, the review might help in identifying possible novel drugs candidates against CARPA.

KW - anaphylatoxins

KW - animal models

KW - hypersensitivity reactions

KW - platelets

KW - pseudoallergy

KW - white blood cells

UR - http://www.scopus.com/inward/record.url?scp=84931052798&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84931052798&partnerID=8YFLogxK

U2 - 10.1515/ejnm-2015-0021

DO - 10.1515/ejnm-2015-0021

M3 - Article

AN - SCOPUS:84931052798

VL - 7

SP - 233

EP - 244

JO - European Journal of Nanomedicine

JF - European Journal of Nanomedicine

SN - 1662-5986

IS - 3

ER -