Bismuth(III)-Catalyzed hydration of terminal alkynes: Sustainable synthesis of methyl ketones in batch and flow

Sándor B. Ötvös, Zsanett Szécsényi, F. Fülöp

Research output: Article

Abstract

Environmentally benign synthesis of methyl ketones is demonstrated via unprecedented bismuth(III)-catalyzed activation and Markovnikov-type hydration of terminal acetylenes. Besides a batch process operating under reasonably mild conditions, a chemically intensified high-temperature continuous-flow methodology has also been developed using a coil reactor. The preparative capabilities of the flow process were demonstrated with multigram-scale alkyne hydrations. The methods presented rely on readily available bismuth(III) salts as "green" catalysts and exhibit less environmental concerns than earlier methods.

Original languageEnglish
Pages (from-to)13286-13293
Number of pages8
JournalACS Sustainable Chemistry and Engineering
Volume7
Issue number15
DOIs
Publication statusPublished - aug. 5 2019

Fingerprint

Bismuth
Alkynes
bismuth
ketone
Ketones
hydration
Hydration
acetylene
Acetylene
Salts
Chemical activation
catalyst
salt
Catalysts
methodology
Temperature
method
reactor
batch process

ASJC Scopus subject areas

  • Chemistry(all)
  • Environmental Chemistry
  • Chemical Engineering(all)
  • Renewable Energy, Sustainability and the Environment

Cite this

Bismuth(III)-Catalyzed hydration of terminal alkynes : Sustainable synthesis of methyl ketones in batch and flow. / Ötvös, Sándor B.; Szécsényi, Zsanett; Fülöp, F.

In: ACS Sustainable Chemistry and Engineering, Vol. 7, No. 15, 05.08.2019, p. 13286-13293.

Research output: Article

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