Birth outcomes of patients with isolated anorectal malformations

A population-based case-control study

Gabor Vermes, Daniel László, E. Czeizel, N. Ács

Research output: Article

2 Citations (Scopus)

Abstract

In most patients affected by isolated anorectal malformation (IARM) the etiology is largely unknown. Thus, the aim of our project was to analyze possible risk factors for IARM. In the first step, birth outcomes of cases with IARM were analyzed on the basis of maternal socio-demographic variables, and these data are presented in this paper. Gestational age at delivery, birthweight, preterm birth, low birthweight and small for gestational age of cases with IARM were evaluated in the function of maternal age, birth/pregnancy order, marital and employment status of mothers in the population-based large dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996. The study samples included 231 live-born cases with IARM, 361 matched and 38151 population controls without any defect. IARMs are more frequent in males, twins and newborn infants with low birthweight and small-for-gestational-age, the latter being the consequence of intrauterine growth restriction. In addition, mothers of cases were younger but with higher birth order, and had lower socio-economic status. These maternal variables are characteristic for the gypsy population in Hungary. The higher proportion of gypsy women among the mothers of cases with IARM was confirmed during the home visits of the study. Male sex and intrauterine growth restriction of cases, in addition to low socioeconomic status and gypsy origin of mothers may have a role in the risk of IARMs.

Original languageEnglish
Pages (from-to)41-45
Number of pages5
JournalCongenital Anomalies
Volume56
Issue number1
DOIs
Publication statusPublished - jan. 1 2016

Fingerprint

Case-Control Studies
Mothers
Parturition
Roma
Birth Order
Population
Gestational Age
House Calls
Population Control
Hungary
Premature Birth
Maternal Age
Marital Status
Population Characteristics
Growth
Social Class
Anorectal Malformations
Economics
Demography
Newborn Infant

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health
  • Embryology

Cite this

Birth outcomes of patients with isolated anorectal malformations : A population-based case-control study. / Vermes, Gabor; László, Daniel; Czeizel, E.; Ács, N.

In: Congenital Anomalies, Vol. 56, No. 1, 01.01.2016, p. 41-45.

Research output: Article

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