Biological activity of 6,12-dihydro-1-benzopyrano[3,4-b][1,4]benzothiazin-6-ones

Anamik Shah, Yogesh Naliapara, Dinesh Sureja, Noboru Motohashi, Teruo Kurihara, Masami Kawase, Kazue Satoh, Hiroshi Sakagami, J. Molnár

Research output: Article

9 Citations (Scopus)

Abstract

Ten 6,12-dihydro-1-benzopyrano[3,4-b][1,4]benzothiazin-6-ones (Coumarins) [1-7] and related coumarins [8-10] were compared for their cytotoxic activity and radical intensity. Among these compounds, compound 7 showed highest cytotoxic activity against human promyelocytic leukemic HL-60 cells. Compound 7 produced radicals under alkaline conditions, and showed the lowest π-spin density at S-atom of the molecule, suggesting the delocalization of π-spin density. These data suggest the possible relation between radical intensity and biological activity.

Original languageEnglish
Pages (from-to)61-63
Number of pages3
JournalAnticancer Research
Volume18
Issue number1 A
Publication statusPublished - jan. 1998

Fingerprint

Coumarins
HL-60 Cells
Human Activities
coumarin 7

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Shah, A., Naliapara, Y., Sureja, D., Motohashi, N., Kurihara, T., Kawase, M., ... Molnár, J. (1998). Biological activity of 6,12-dihydro-1-benzopyrano[3,4-b][1,4]benzothiazin-6-ones. Anticancer Research, 18(1 A), 61-63.

Biological activity of 6,12-dihydro-1-benzopyrano[3,4-b][1,4]benzothiazin-6-ones. / Shah, Anamik; Naliapara, Yogesh; Sureja, Dinesh; Motohashi, Noboru; Kurihara, Teruo; Kawase, Masami; Satoh, Kazue; Sakagami, Hiroshi; Molnár, J.

In: Anticancer Research, Vol. 18, No. 1 A, 01.1998, p. 61-63.

Research output: Article

Shah, A, Naliapara, Y, Sureja, D, Motohashi, N, Kurihara, T, Kawase, M, Satoh, K, Sakagami, H & Molnár, J 1998, 'Biological activity of 6,12-dihydro-1-benzopyrano[3,4-b][1,4]benzothiazin-6-ones', Anticancer Research, vol. 18, no. 1 A, pp. 61-63.
Shah A, Naliapara Y, Sureja D, Motohashi N, Kurihara T, Kawase M et al. Biological activity of 6,12-dihydro-1-benzopyrano[3,4-b][1,4]benzothiazin-6-ones. Anticancer Research. 1998 jan.;18(1 A):61-63.
Shah, Anamik ; Naliapara, Yogesh ; Sureja, Dinesh ; Motohashi, Noboru ; Kurihara, Teruo ; Kawase, Masami ; Satoh, Kazue ; Sakagami, Hiroshi ; Molnár, J. / Biological activity of 6,12-dihydro-1-benzopyrano[3,4-b][1,4]benzothiazin-6-ones. In: Anticancer Research. 1998 ; Vol. 18, No. 1 A. pp. 61-63.
@article{29bca594544c4b35a4afcefb263bde86,
title = "Biological activity of 6,12-dihydro-1-benzopyrano[3,4-b][1,4]benzothiazin-6-ones",
abstract = "Ten 6,12-dihydro-1-benzopyrano[3,4-b][1,4]benzothiazin-6-ones (Coumarins) [1-7] and related coumarins [8-10] were compared for their cytotoxic activity and radical intensity. Among these compounds, compound 7 showed highest cytotoxic activity against human promyelocytic leukemic HL-60 cells. Compound 7 produced radicals under alkaline conditions, and showed the lowest π-spin density at S-atom of the molecule, suggesting the delocalization of π-spin density. These data suggest the possible relation between radical intensity and biological activity.",
keywords = "π-spin density, Coumarins, Cytotoxic activity, ESR",
author = "Anamik Shah and Yogesh Naliapara and Dinesh Sureja and Noboru Motohashi and Teruo Kurihara and Masami Kawase and Kazue Satoh and Hiroshi Sakagami and J. Moln{\'a}r",
year = "1998",
month = "1",
language = "English",
volume = "18",
pages = "61--63",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "1 A",

}

TY - JOUR

T1 - Biological activity of 6,12-dihydro-1-benzopyrano[3,4-b][1,4]benzothiazin-6-ones

AU - Shah, Anamik

AU - Naliapara, Yogesh

AU - Sureja, Dinesh

AU - Motohashi, Noboru

AU - Kurihara, Teruo

AU - Kawase, Masami

AU - Satoh, Kazue

AU - Sakagami, Hiroshi

AU - Molnár, J.

PY - 1998/1

Y1 - 1998/1

N2 - Ten 6,12-dihydro-1-benzopyrano[3,4-b][1,4]benzothiazin-6-ones (Coumarins) [1-7] and related coumarins [8-10] were compared for their cytotoxic activity and radical intensity. Among these compounds, compound 7 showed highest cytotoxic activity against human promyelocytic leukemic HL-60 cells. Compound 7 produced radicals under alkaline conditions, and showed the lowest π-spin density at S-atom of the molecule, suggesting the delocalization of π-spin density. These data suggest the possible relation between radical intensity and biological activity.

AB - Ten 6,12-dihydro-1-benzopyrano[3,4-b][1,4]benzothiazin-6-ones (Coumarins) [1-7] and related coumarins [8-10] were compared for their cytotoxic activity and radical intensity. Among these compounds, compound 7 showed highest cytotoxic activity against human promyelocytic leukemic HL-60 cells. Compound 7 produced radicals under alkaline conditions, and showed the lowest π-spin density at S-atom of the molecule, suggesting the delocalization of π-spin density. These data suggest the possible relation between radical intensity and biological activity.

KW - π-spin density

KW - Coumarins

KW - Cytotoxic activity

KW - ESR

UR - http://www.scopus.com/inward/record.url?scp=0031898846&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031898846&partnerID=8YFLogxK

M3 - Article

C2 - 9568056

AN - SCOPUS:0031898846

VL - 18

SP - 61

EP - 63

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 1 A

ER -