Bilateral subthalamic stimulation can improve sleep quality in Parkinson's disease

Gabriella Deli, Zsuzsanna Aschermann, Peter Acs, Edit Bosnyak, Jozsef Janszky, Bela Faludi, Attila Makkos, Marton Kovacs, Samuel Komoly, Istvan Balas, Tamas Doczi, Norbert Kovacs

Research output: Article

22 Citations (Scopus)

Abstract

Sleep problems are among the most common non-motor symptoms of Parkinson's disease (PD). The PD Sleep Scale 2nd version (PDSS-2) improved the original PDSS by adding more items on different aspects of sleep problems, making it a more robust tool to evaluate the severity of sleep disturbances. However, previous studies on deep brain stimulation (DBS) have not used the PDSS-2. Objective: To determine if the PDSS-2 could detect improvement reliably in sleep problems after bilateral subthalamic nucleus DBS for PD. Methods: In this prospective study, 25 consecutive patients undergoing DBS implantation were enrolled. Patients were examined twice: 1 week prior to the DBS implantation (baseline) and 12 months postoperatively. Severity of PD symptoms were assessed by the Movement Disorders Society Unified PD Rating Scale (MDS-UPDRS) and the Non-Motor Symptoms Scale (NMSS). Presence and severity of sleep disturbances were specifically measured by PDSS-2. Results: Total score of MDS-UPDRS improved from 81 (median, interquartile-range: 63-103) to 55 points (median, IQR: 46-75, p < 0.001). Health-related quality of life, measured by PDQ-39, also improved from 29 (IQR: 18-40) to 15 (IQR: 9-28) points (p = 0.002). Most domains of NMSS also improved. At baseline 13 patients reported sleep problems, but 1 year after DBS implantation only 3 did (p = 0.012). Although only 6 out of 15 items showed a significant decrease after DBS implantation, the total score of PDSS-2 decreased from 24 (IQR: 17-32) to 10 (IQR: 7-18) points (P < 0.001). Conclusions: Based on our results, PDSS-2 can detect improvements in sleep quality reliably after DBS implantation.

Original languageEnglish
Pages (from-to)361-368
Number of pages8
JournalJournal of Parkinson's Disease
Volume5
Issue number2
DOIs
Publication statusPublished - jún. 1 2015

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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