Beneficial effects of aminoguanidine on the cardiovascular system of diabetic rats

Krisztián Stadler, Veronika Jenei, Anikó Somogyi, Judit Jakus

Research output: Article

29 Citations (Scopus)

Abstract

Background: The study focused on investigating the effect of aminoguanidine on cardiovascular damages in diabetes and the possible mechanisms of its action. Methods: Aminoguanidine (AMNG) was used to treat streptozotocin-induced diabetic rats, and the effects were compared to those obtained under insulin treatment. Blood metabolic parameters, NO and ONOO- as well as protein carbonyl levels and cardiac hypertrophy were determined. Results: Diabetic animals showed increased NO levels and markedly increased ONOO- generation in the aorta, along with a significant hypertrophy and protein carbonylation in the cardiac tissue. Both AMNG and insulin treatment suppressed the levels of overproduced NO or ONOO- in the vasculature, but only AMNG was able to prevent hypertrophic alterations and reduce protein carbonylation in the cardiac tissue. Conclusions: Oxidative protein modification, together with cardiac hypertrophy and high generation of NO and ONOO-, are important early events in the development of cardiovascular complications in diabetes. Aminoguanidine could prevent hypertrophy through inhibition of production of nonenzymatic glycation products rather than via inhibition of NO production.

Original languageEnglish
Pages (from-to)189-196
Number of pages8
JournalDiabetes/Metabolism Research and Reviews
Volume21
Issue number2
DOIs
Publication statusPublished - márc. 1 2005

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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