A petesejtfagyasztás elméleti alapjai és szerepe az asszisztált reprodukcióban

János Konc, Katalin Kanyó, S. Cseh

Research output: Article

2 Citations (Scopus)

Abstract

In many countries, embryo freezing is illegal or it is limited to a given developmental stage of the embryo. Oocyte cryopreservation offers more advantages compared to embryo freezing with less ethical, legal, and moral problems (except technical problems). 1) It can help to alleviate religious and/or other ethical concerns of embryo storage, 2) It helps to overcome problems for example when the husband is unable to produce a viable sperm sample or when spermatozoa cannot be found in the testis at a given moment in case of non-obstructive azoospermia, 3) Oocyte freezing makes egg banks possible, 4) Oocyte cryopreservation permits women at risk of becoming sterile to cryopreserve oocytes prior to radiotherapy/chemotherapy, 5) It allows women to delay reproduction until later in life, for example after establishing carreer. However, oocyte cryopreservation technically proved to be more difficult than embryo freezing. Many questions need answers to be found. One set of questions is related to the biological characteristics of the oocyte (size, spindle, ratio of the surface area and volume, maturity level, quality, etc.) while others are related to the techniques being applied (temperature of seeding, type of cryoprotective material, speed of freezing, etc.). The efficiency of the procedure is still low, thus preventing the introduction of the method into the wide clinical practice. Data found in the literature indicate big variations in the survival rate (25-80%), fertilization rate (13-71%), cleavage rate (30-90%) and pregnancy rate (5-20%). However, recently published results are very promising and show that with a little modification of the freezing technology the efficacy (from survival rate to pregnancy rate) could be improved.

Original languageHungarian
Pages (from-to)531-541
Number of pages11
JournalMagyar Noorvosok Lapja
Volume69
Issue number6
Publication statusPublished - 2006

Fingerprint

Cryopreservation
Freezing
Oocytes
Reproduction
Embryonic Structures
Pregnancy Rate
Spermatozoa
Survival Rate
Azoospermia
Spouses
Fertilization
Ovum
Testis
Radiotherapy
Technology
Drug Therapy
Temperature

Keywords

  • Cryobiology of the embryo
  • Cryoprotective materials
  • Frozen-thawed embryos
  • In vitro fertilization and embryo transfer (IVF-ET)
  • Intra cytoplasmic sperm injection (ICSI)

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

A petesejtfagyasztás elméleti alapjai és szerepe az asszisztált reprodukcióban. / Konc, János; Kanyó, Katalin; Cseh, S.

In: Magyar Noorvosok Lapja, Vol. 69, No. 6, 2006, p. 531-541.

Research output: Article

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