Baseline characteristics and disease phenotype in inflammatory bowel disease

Hungarian Pediatric IBD Registry Group

Research output: Article

4 Citations (Scopus)

Abstract

Objectives: Predicting short-term relapses and long-term prognosis is of utmost importance in paediatric inflammatory bowel disease (IBD). Our aim was to investigate the short-term disease outcome and medication during the first year in a paediatric incident cohort from Hungary. In addition, association laboratory markers and disease activity indices with short-term disease outcome and medication were analysed. Methods: From January 1, 2008 to December 31, 2010, demographic data and clinical characteristics of newly diagnosed paediatric patients with IBD 31), and this rate decreased to 2.1% at 1-year follow-up. Proportion of patients with UC with moderate-to-severe disease (Pediatric Ulcerative Colitis Activity Index >35) at diagnosis declined from 57.5% (69/120) to 6.8% at 1-year follow-up. Terminal ileal involvement correlated with higher initial C-reactive protein (CRP) (P =0.021) and initial PCDAI (P =0.026). In UC, elevated CRP (P =0.002) was associated with disease extension. CRP and PCDAI at diagnosis were associated with the need for immunomodulators at 1 year in children with CD. Initial CRP was also associated with the need for immunomodulators in patients with UC at 1-year follow-up. Conclusions: At diagnosis, half of the patients with IBD had moderate-tosevere disease, and this rate decreased to

Original languageEnglish
Pages (from-to)50-55
Number of pages6
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume62
Issue number1
DOIs
Publication statusPublished - 2016

Fingerprint

Inflammatory Bowel Diseases
Phenotype
C-Reactive Protein
Immunologic Factors
Pediatrics
Hungary
Biomarkers
Demography
Recurrence

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health

Cite this

Baseline characteristics and disease phenotype in inflammatory bowel disease. / Hungarian Pediatric IBD Registry Group.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 62, No. 1, 2016, p. 50-55.

Research output: Article

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abstract = "Objectives: Predicting short-term relapses and long-term prognosis is of utmost importance in paediatric inflammatory bowel disease (IBD). Our aim was to investigate the short-term disease outcome and medication during the first year in a paediatric incident cohort from Hungary. In addition, association laboratory markers and disease activity indices with short-term disease outcome and medication were analysed. Methods: From January 1, 2008 to December 31, 2010, demographic data and clinical characteristics of newly diagnosed paediatric patients with IBD 31), and this rate decreased to 2.1{\%} at 1-year follow-up. Proportion of patients with UC with moderate-to-severe disease (Pediatric Ulcerative Colitis Activity Index >35) at diagnosis declined from 57.5{\%} (69/120) to 6.8{\%} at 1-year follow-up. Terminal ileal involvement correlated with higher initial C-reactive protein (CRP) (P =0.021) and initial PCDAI (P =0.026). In UC, elevated CRP (P =0.002) was associated with disease extension. CRP and PCDAI at diagnosis were associated with the need for immunomodulators at 1 year in children with CD. Initial CRP was also associated with the need for immunomodulators in patients with UC at 1-year follow-up. Conclusions: At diagnosis, half of the patients with IBD had moderate-tosevere disease, and this rate decreased to",
keywords = "C-reactive protein, disease activity index, epidemiology, follow-up, paediatric inflammatory bowel disease, therapy",
author = "{Hungarian Pediatric IBD Registry Group} and M{\"u}ller, {Katalin E.} and P. Lakatos and J. Kov{\'a}cs and A. Arat{\'o} and A. V{\'a}rkonyi and E. Nemes and Andras Tarnok and Gergely Toth and M. Papp and Eniko Solyom and Agnes Horvath and Ildiko Guthy and Marta Kovacs and G. Ver{\`e}s",
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T1 - Baseline characteristics and disease phenotype in inflammatory bowel disease

AU - Hungarian Pediatric IBD Registry Group

AU - Müller, Katalin E.

AU - Lakatos, P.

AU - Kovács, J.

AU - Arató, A.

AU - Várkonyi, A.

AU - Nemes, E.

AU - Tarnok, Andras

AU - Toth, Gergely

AU - Papp, M.

AU - Solyom, Eniko

AU - Horvath, Agnes

AU - Guthy, Ildiko

AU - Kovacs, Marta

AU - Verès, G.

PY - 2016

Y1 - 2016

N2 - Objectives: Predicting short-term relapses and long-term prognosis is of utmost importance in paediatric inflammatory bowel disease (IBD). Our aim was to investigate the short-term disease outcome and medication during the first year in a paediatric incident cohort from Hungary. In addition, association laboratory markers and disease activity indices with short-term disease outcome and medication were analysed. Methods: From January 1, 2008 to December 31, 2010, demographic data and clinical characteristics of newly diagnosed paediatric patients with IBD 31), and this rate decreased to 2.1% at 1-year follow-up. Proportion of patients with UC with moderate-to-severe disease (Pediatric Ulcerative Colitis Activity Index >35) at diagnosis declined from 57.5% (69/120) to 6.8% at 1-year follow-up. Terminal ileal involvement correlated with higher initial C-reactive protein (CRP) (P =0.021) and initial PCDAI (P =0.026). In UC, elevated CRP (P =0.002) was associated with disease extension. CRP and PCDAI at diagnosis were associated with the need for immunomodulators at 1 year in children with CD. Initial CRP was also associated with the need for immunomodulators in patients with UC at 1-year follow-up. Conclusions: At diagnosis, half of the patients with IBD had moderate-tosevere disease, and this rate decreased to

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