B-lines quantify the lung water content

A lung ultrasound versus lung gravimetry study in acute lung injury

Z. Jambrik, Luna Gargani, A. Adamicza, J. Kaszaki, A. Varga, T. Forster, M. Borós, Eugenio Picano

Research output: Article

58 Citations (Scopus)

Abstract

B-lines (also termed ultrasound lung comets) obtained with lung ultrasound detect experimental acute lung injury (ALI) very early and before hemogasanalytic changes, with a simple, noninvasive, nonionizing and real-time method. Our aim was to estimate the correlation between B-lines number and the wet/dry ratio of the lung tissue, measured by gravimetry, in an experimental model of ALI.Seventeen Na-pentobarbital anesthetized, cannulated (central vein and carotid artery) minipigs were studied: five sham-operated animals served as controls and, in 12 animals, ALI was induced by injection of oleic acid (0.1 mL/kg) via the central venous catheter. B-lines were measured by echographic scanner in four predetermined chest scanning sites in each animal. At the end of each experiment, both lungs were dissected, weighed and dried to determine wet/dry weight ratio by gravimetry. After the injection of oleic acid, B-lines number increased over time. A significant correlation was found between the wet/dry ratio and B-lines number (r = 0.91, p <0.001). These data suggest that in an experimental pig model of ALI/ARDS, B-lines assessed by lung ultrasound provide a simple, semiquantitative, noninvasive index of lung water accumulation, strongly correlated to invasive gravimetric assessment.

Original languageEnglish
Pages (from-to)2004-2010
Number of pages7
JournalUltrasound in Medicine and Biology
Volume36
Issue number12
DOIs
Publication statusPublished - dec. 2010

Fingerprint

gravimetry
Acute Lung Injury
lungs
moisture content
Lung
Water
Oleic Acid
Theoretical Models
animals
oleic acid
Miniature Swine
Injections
Central Venous Catheters
pentobarbital
Pentobarbital
Carotid Arteries
Veins
injection
Swine
Thorax

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Biophysics

Cite this

@article{9a527658bcd040c8a4f00a5d2b1e89b0,
title = "B-lines quantify the lung water content: A lung ultrasound versus lung gravimetry study in acute lung injury",
abstract = "B-lines (also termed ultrasound lung comets) obtained with lung ultrasound detect experimental acute lung injury (ALI) very early and before hemogasanalytic changes, with a simple, noninvasive, nonionizing and real-time method. Our aim was to estimate the correlation between B-lines number and the wet/dry ratio of the lung tissue, measured by gravimetry, in an experimental model of ALI.Seventeen Na-pentobarbital anesthetized, cannulated (central vein and carotid artery) minipigs were studied: five sham-operated animals served as controls and, in 12 animals, ALI was induced by injection of oleic acid (0.1 mL/kg) via the central venous catheter. B-lines were measured by echographic scanner in four predetermined chest scanning sites in each animal. At the end of each experiment, both lungs were dissected, weighed and dried to determine wet/dry weight ratio by gravimetry. After the injection of oleic acid, B-lines number increased over time. A significant correlation was found between the wet/dry ratio and B-lines number (r = 0.91, p <0.001). These data suggest that in an experimental pig model of ALI/ARDS, B-lines assessed by lung ultrasound provide a simple, semiquantitative, noninvasive index of lung water accumulation, strongly correlated to invasive gravimetric assessment.",
keywords = "Acute lung injury, B-lines, Extravascular lung water, Gravimetry, Lung ultrasound, Ultrasound lung comets",
author = "Z. Jambrik and Luna Gargani and A. Adamicza and J. Kaszaki and A. Varga and T. Forster and M. Bor{\'o}s and Eugenio Picano",
year = "2010",
month = "12",
doi = "10.1016/j.ultrasmedbio.2010.09.003",
language = "English",
volume = "36",
pages = "2004--2010",
journal = "Ultrasound in Medicine and Biology",
issn = "0301-5629",
publisher = "Elsevier USA",
number = "12",

}

TY - JOUR

T1 - B-lines quantify the lung water content

T2 - A lung ultrasound versus lung gravimetry study in acute lung injury

AU - Jambrik, Z.

AU - Gargani, Luna

AU - Adamicza, A.

AU - Kaszaki, J.

AU - Varga, A.

AU - Forster, T.

AU - Borós, M.

AU - Picano, Eugenio

PY - 2010/12

Y1 - 2010/12

N2 - B-lines (also termed ultrasound lung comets) obtained with lung ultrasound detect experimental acute lung injury (ALI) very early and before hemogasanalytic changes, with a simple, noninvasive, nonionizing and real-time method. Our aim was to estimate the correlation between B-lines number and the wet/dry ratio of the lung tissue, measured by gravimetry, in an experimental model of ALI.Seventeen Na-pentobarbital anesthetized, cannulated (central vein and carotid artery) minipigs were studied: five sham-operated animals served as controls and, in 12 animals, ALI was induced by injection of oleic acid (0.1 mL/kg) via the central venous catheter. B-lines were measured by echographic scanner in four predetermined chest scanning sites in each animal. At the end of each experiment, both lungs were dissected, weighed and dried to determine wet/dry weight ratio by gravimetry. After the injection of oleic acid, B-lines number increased over time. A significant correlation was found between the wet/dry ratio and B-lines number (r = 0.91, p <0.001). These data suggest that in an experimental pig model of ALI/ARDS, B-lines assessed by lung ultrasound provide a simple, semiquantitative, noninvasive index of lung water accumulation, strongly correlated to invasive gravimetric assessment.

AB - B-lines (also termed ultrasound lung comets) obtained with lung ultrasound detect experimental acute lung injury (ALI) very early and before hemogasanalytic changes, with a simple, noninvasive, nonionizing and real-time method. Our aim was to estimate the correlation between B-lines number and the wet/dry ratio of the lung tissue, measured by gravimetry, in an experimental model of ALI.Seventeen Na-pentobarbital anesthetized, cannulated (central vein and carotid artery) minipigs were studied: five sham-operated animals served as controls and, in 12 animals, ALI was induced by injection of oleic acid (0.1 mL/kg) via the central venous catheter. B-lines were measured by echographic scanner in four predetermined chest scanning sites in each animal. At the end of each experiment, both lungs were dissected, weighed and dried to determine wet/dry weight ratio by gravimetry. After the injection of oleic acid, B-lines number increased over time. A significant correlation was found between the wet/dry ratio and B-lines number (r = 0.91, p <0.001). These data suggest that in an experimental pig model of ALI/ARDS, B-lines assessed by lung ultrasound provide a simple, semiquantitative, noninvasive index of lung water accumulation, strongly correlated to invasive gravimetric assessment.

KW - Acute lung injury

KW - B-lines

KW - Extravascular lung water

KW - Gravimetry

KW - Lung ultrasound

KW - Ultrasound lung comets

UR - http://www.scopus.com/inward/record.url?scp=78449266453&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78449266453&partnerID=8YFLogxK

U2 - 10.1016/j.ultrasmedbio.2010.09.003

DO - 10.1016/j.ultrasmedbio.2010.09.003

M3 - Article

VL - 36

SP - 2004

EP - 2010

JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

SN - 0301-5629

IS - 12

ER -