Autologous hematopoietic stem cell transplantation in chronic myeloid leukemia with different clinical stages

Laszlo Gopcsa, Aniko Barta, Aniko Banyai, Janos Foldi, Laszlo Kalasz, Laszlo Pajor, Julia Gidali, Nora Regeczy, Katalin Paloczi

Research output: Article

Abstract

Seven patients with Philadelphia (Ph) chromosome-positive chronic myeloid leukemia (CML) were treated with an ICE-based regimen plus G-CSF with the aim of mobilizing and collecting Ph-negative peripheral stem cells in the setting of an autologous transplant program. Five patients had CML in the first chronic phase and 2 in the accelerated phase. All patients had been previously treated with interferon-α. Median value and ranges for harvested mononuclear cells, CD34+ cells and CFU-GM, respectively: 5.65 × 108/kg (2.61-11.38); 1.48 × 106/kg (0.216-3.5), and 3.43 × 104/kg (0.243-11.6). FISH was the only useful method for detection of minimal residual disease on apheresis product showing <5% t(9;22) positive cells in 2 cases and <10% positive cells in 4 other cases. Four of seven autologous grafts have been transplanted to date. Busulfan conditioning was used in 1 case and TBI/Cy conditioning in 3 other cases. All patients are alive and well following transplantation and are on interferon-α therapy.

Original languageEnglish
Pages (from-to)100-105
Number of pages6
JournalActa Haematologica
Volume106
Issue number3
DOIs
Publication statusPublished - dec. 3 2001

    Fingerprint

ASJC Scopus subject areas

  • Hematology

Cite this

Gopcsa, L., Barta, A., Banyai, A., Foldi, J., Kalasz, L., Pajor, L., Gidali, J., Regeczy, N., & Paloczi, K. (2001). Autologous hematopoietic stem cell transplantation in chronic myeloid leukemia with different clinical stages. Acta Haematologica, 106(3), 100-105. https://doi.org/10.1159/000046597