Aszimmetrikus dimetilarginin: A cardiovascularis betegségek prediktora?

Németh Balázs, Kustán Péter, Németh Ádám, Lenkey Zsófia, Cziráki Attila, Kiss István, Sulyok Endre, Ajtay Zénó

Research output: Article

4 Citations (Scopus)

Abstract

Cardiovascular diseases are the most common diseases worldwide. They are responsible for one third of global deaths and they are the leading cause of disability, too. The usage of different levels of prevention in combination with effective risk assessment improved these statistical data. Risk assessment based on classic risk factors has recently been supported with several new markers, such as asymmetric dimethylarginine, which is an endogenous competitive inhibitor of nitric oxide synthase. Elevated levels of asymmetric dimethylarginine have been reported in obese, smoker, hypercholesterolemic, hypertensive and diabetic patients. According to previous studies, asymmetric dimethylarginine is a suitable indicator of endothelial dysfunction, which is held to be the previous state of atherosclerosis. Several researches found positive correlation between higher levels of asymmetric dimethylarginine and coronary artery disease onset, or progression of existing coronary disease. According to a study involving 3000 patients, asymmetric dimethylarginine is an independent risk factor of cardiovascular mortality in patients with coronary artery disease. This article summarizes the role of asymmetric dimethylarginine in prediction of cardiovascular diseases, and underlines its importance in cardiovascular prevention.

Translated title of the contributionAsymmetric dimethylarginine: Predictor of cardiovascular diseases?
Original languageHungarian
Pages (from-to)483-487
Number of pages5
JournalOrvosi hetilap
Volume157
Issue number13
DOIs
Publication statusPublished - márc. 2016

Keywords

  • Asymmetric dimethylarginine
  • Oxidative stress
  • Risk stratification

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Balázs, N., Péter, K., Ádám, N., Zsófia, L., Attila, C., István, K., Endre, S., & Zénó, A. (2016). Aszimmetrikus dimetilarginin: A cardiovascularis betegségek prediktora? Orvosi hetilap, 157(13), 483-487. https://doi.org/10.1556/650.2016.30396