Association study of the ABCA7 rs3752246 polymorphism in Alzheimer's disease

Ágnes Fehér, Anna Juhász, M. Pákáski, Z. Janka, János Kálmán

Research output: Letter

Abstract

The ATP-binding cassette, sub-family A, member 7 (ABCA7) gene has been identified as a strong genetic risk locus for Alzheimer's disease (AD). Our case-control study (416 AD patients and 302 controls) provides further data on the rs3752246 polymorphism in AD in the Hungarian population that has not been investigated so far regarding the ABCA7 gene variants. A modest, marginally significant association of the G allele containing genotypes with AD was observed (p = 0.054). In line with the previous results in other populations, the G allele carriers had an increased risk for developing AD considering C/C genotype as reference category.

Original languageEnglish
Pages (from-to)376-377
Number of pages2
JournalPsychiatry research
Volume279
DOIs
Publication statusPublished - szept. 1 2019

Fingerprint

Alzheimer Disease
Adenosine Triphosphate
Alleles
Genotype
Genetic Loci
Population
Genes
Case-Control Studies

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Association study of the ABCA7 rs3752246 polymorphism in Alzheimer's disease. / Fehér, Ágnes; Juhász, Anna; Pákáski, M.; Janka, Z.; Kálmán, János.

In: Psychiatry research, Vol. 279, 01.09.2019, p. 376-377.

Research output: Letter

Fehér, Ágnes ; Juhász, Anna ; Pákáski, M. ; Janka, Z. ; Kálmán, János. / Association study of the ABCA7 rs3752246 polymorphism in Alzheimer's disease. In: Psychiatry research. 2019 ; Vol. 279. pp. 376-377.
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