Association of vitamin D receptor gene polymorphisms and Parkinson's disease in Hungarians

Rita Török, Nora Török, Levente Szalardy, Imola Plangar, Zoltan Szolnoki, Ferenc Somogyvari, Laszlo Vecsei, Peter Klivenyi

Research output: Article

31 Citations (Scopus)

Abstract

Vitamin D receptor (VDR) gene encodes a transcription factor that influences calcium homeostasis and immunoregulation, and may play a role in neurological disorders including Parkinson's disease (PD). The investigations of the association between VDR and PD in different populations revealed various results. In a present study 100 PD patients and 109 healthy controls from the Hungarian population were genotyped for four polymorphic sites (BsmI, ApaI, FokI and TaqI) in the VDR gene. The polymorphisms were determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Our results demonstrate an association between the FokI C allele and PD; the frequency of the C allele was significantly higher in PD patients than in controls, suggesting that this polymorphism may have a role in the development of PD in these patients.

Original languageEnglish
Pages (from-to)70-74
Number of pages5
JournalNeuroscience Letters
Volume551
DOIs
Publication statusPublished - szept. 13 2013

ASJC Scopus subject areas

  • Neuroscience(all)

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