Association of primary biliary cirrhosis with vitamin D receptor BsmI genotype polymorphism in a Hungarian population

Balazs Halmos, Ferenc Szalay, Tamas Cserniczky, Elemer Nemesanszky, Peter Lakatos, Stefan Barlage, Gerd Schmitz, Laszlo Romics, Albert Csaszar

Research output: Article

47 Citations (Scopus)

Abstract

We sought to determine the distribution of vitamin D receptor genotypes defined by the BsmI polymorphism and to investigate their association with bone mineral density in patients with primary biliary cirrhosis. Vitamin D receptor genotype and bone mineral density at the lumbar spine was determined in 31 female Hungarian patients with primary biliary cirrhosis and 51 age- matched healthy female controls. The genotype frequency (BB: 45%, Bb: 32%, bb: 22%) of the patients was significantly different from the control group (P = 0.01) due to an overrepresentation of the BB genotype. There was an apparent trend, not reaching statistical significance, for a lower bone mineral density in both the patient and control groups carrying a B allele. In conclusion, we found a strikingly high frequency of the BB genotype in patients with primary biliary cirrhosis, which raises questions about hormonal influences on the development of primary biliary cirrhosis.

Original languageEnglish
Pages (from-to)1091-1095
Number of pages5
JournalDigestive Diseases and Sciences
Volume45
Issue number6
DOIs
Publication statusPublished - júl. 6 2000

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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