Association of n-6 long-chain polyunsaturated fatty acids to -866 G/A genotypes of the human uncoupling protein 2 gene in obese children

Szilvia Bokor, Katalin Csernus, E. Erhardt, István Burus, D. Molnár, T. Decsi

Research output: Article

1 Citation (Scopus)

Abstract

Aim: To investigate the association of plasma fatty acids with the -866 G/A polymorphism of uncoupling protein 2 (UCP2) in obese children. Methods: Fatty acid composition of plasma phospholipids and sterol esters were investigated in 80 obese children. Results: Values of dihomo-γ-linolenic acid (C20:3n-6) were significantly lower in children with the -866 A/A (n = 12) than in those with the -866 G/A (n = 34) or -866 G/G (n = 34) genotype in plasma phospholipids (3.01 [0.42] vs. 3.56 [1.02] vs. 3.53 [0.84], % weight/weight, median [interquartile range], p <0.05), and were significantly lower in children with the -866 A/A genotype than in the other two groups in plasma sterol esters (0.73 [0.22] vs. 0.92 [0.23] vs. 0.94 [0.25], p <0.05). Phospholipid C20:3n-6 and arachidonic acid (C20:4n-6) values showed only in children with the -866 G/G and -866 G/A genotypes significant positive correlations with plasma insulin concentrations. Conclusions: Significantly lower values of C20:3n-6 can be detected in obese children with the homozygous (-866 A/A) mutation of UCP2 than in equally obese children with heterozygous mutation or the normal genotype. High glucose-stimulated insulin response is associated with high plasma C20:3n-6 and C20:4n-6 values only in obese children with the G allele of the -866 G/A polymorphism.

Original languageEnglish
Pages (from-to)1350-1354
Number of pages5
JournalActa Paediatrica, International Journal of Paediatrics
Volume96
Issue number9
DOIs
Publication statusPublished - szept. 2007

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Unsaturated Fatty Acids
Genotype
Genes
Phospholipids
Sterols
Esters
Fatty Acids
Insulin
Weights and Measures
Mutation
alpha-Linolenic Acid
Uncoupling Protein 2
Arachidonic Acid
Alleles
Glucose

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

@article{2994f28ab9294fd7ba22ea6018d0e1bb,
title = "Association of n-6 long-chain polyunsaturated fatty acids to -866 G/A genotypes of the human uncoupling protein 2 gene in obese children",
abstract = "Aim: To investigate the association of plasma fatty acids with the -866 G/A polymorphism of uncoupling protein 2 (UCP2) in obese children. Methods: Fatty acid composition of plasma phospholipids and sterol esters were investigated in 80 obese children. Results: Values of dihomo-γ-linolenic acid (C20:3n-6) were significantly lower in children with the -866 A/A (n = 12) than in those with the -866 G/A (n = 34) or -866 G/G (n = 34) genotype in plasma phospholipids (3.01 [0.42] vs. 3.56 [1.02] vs. 3.53 [0.84], {\%} weight/weight, median [interquartile range], p <0.05), and were significantly lower in children with the -866 A/A genotype than in the other two groups in plasma sterol esters (0.73 [0.22] vs. 0.92 [0.23] vs. 0.94 [0.25], p <0.05). Phospholipid C20:3n-6 and arachidonic acid (C20:4n-6) values showed only in children with the -866 G/G and -866 G/A genotypes significant positive correlations with plasma insulin concentrations. Conclusions: Significantly lower values of C20:3n-6 can be detected in obese children with the homozygous (-866 A/A) mutation of UCP2 than in equally obese children with heterozygous mutation or the normal genotype. High glucose-stimulated insulin response is associated with high plasma C20:3n-6 and C20:4n-6 values only in obese children with the G allele of the -866 G/A polymorphism.",
keywords = "Arachidonic acid, Dihomo-gamma-linolenic acid, Insulin resistance, Uncoupling protein 2",
author = "Szilvia Bokor and Katalin Csernus and E. Erhardt and Istv{\'a}n Burus and D. Moln{\'a}r and T. Decsi",
year = "2007",
month = "9",
doi = "10.1111/j.1651-2227.2007.00422.x",
language = "English",
volume = "96",
pages = "1350--1354",
journal = "Acta Paediatrica, International Journal of Paediatrics",
issn = "0803-5253",
publisher = "Wiley-Blackwell",
number = "9",

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TY - JOUR

T1 - Association of n-6 long-chain polyunsaturated fatty acids to -866 G/A genotypes of the human uncoupling protein 2 gene in obese children

AU - Bokor, Szilvia

AU - Csernus, Katalin

AU - Erhardt, E.

AU - Burus, István

AU - Molnár, D.

AU - Decsi, T.

PY - 2007/9

Y1 - 2007/9

N2 - Aim: To investigate the association of plasma fatty acids with the -866 G/A polymorphism of uncoupling protein 2 (UCP2) in obese children. Methods: Fatty acid composition of plasma phospholipids and sterol esters were investigated in 80 obese children. Results: Values of dihomo-γ-linolenic acid (C20:3n-6) were significantly lower in children with the -866 A/A (n = 12) than in those with the -866 G/A (n = 34) or -866 G/G (n = 34) genotype in plasma phospholipids (3.01 [0.42] vs. 3.56 [1.02] vs. 3.53 [0.84], % weight/weight, median [interquartile range], p <0.05), and were significantly lower in children with the -866 A/A genotype than in the other two groups in plasma sterol esters (0.73 [0.22] vs. 0.92 [0.23] vs. 0.94 [0.25], p <0.05). Phospholipid C20:3n-6 and arachidonic acid (C20:4n-6) values showed only in children with the -866 G/G and -866 G/A genotypes significant positive correlations with plasma insulin concentrations. Conclusions: Significantly lower values of C20:3n-6 can be detected in obese children with the homozygous (-866 A/A) mutation of UCP2 than in equally obese children with heterozygous mutation or the normal genotype. High glucose-stimulated insulin response is associated with high plasma C20:3n-6 and C20:4n-6 values only in obese children with the G allele of the -866 G/A polymorphism.

AB - Aim: To investigate the association of plasma fatty acids with the -866 G/A polymorphism of uncoupling protein 2 (UCP2) in obese children. Methods: Fatty acid composition of plasma phospholipids and sterol esters were investigated in 80 obese children. Results: Values of dihomo-γ-linolenic acid (C20:3n-6) were significantly lower in children with the -866 A/A (n = 12) than in those with the -866 G/A (n = 34) or -866 G/G (n = 34) genotype in plasma phospholipids (3.01 [0.42] vs. 3.56 [1.02] vs. 3.53 [0.84], % weight/weight, median [interquartile range], p <0.05), and were significantly lower in children with the -866 A/A genotype than in the other two groups in plasma sterol esters (0.73 [0.22] vs. 0.92 [0.23] vs. 0.94 [0.25], p <0.05). Phospholipid C20:3n-6 and arachidonic acid (C20:4n-6) values showed only in children with the -866 G/G and -866 G/A genotypes significant positive correlations with plasma insulin concentrations. Conclusions: Significantly lower values of C20:3n-6 can be detected in obese children with the homozygous (-866 A/A) mutation of UCP2 than in equally obese children with heterozygous mutation or the normal genotype. High glucose-stimulated insulin response is associated with high plasma C20:3n-6 and C20:4n-6 values only in obese children with the G allele of the -866 G/A polymorphism.

KW - Arachidonic acid

KW - Dihomo-gamma-linolenic acid

KW - Insulin resistance

KW - Uncoupling protein 2

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U2 - 10.1111/j.1651-2227.2007.00422.x

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JO - Acta Paediatrica, International Journal of Paediatrics

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