Association of high serum concentration of the third component of complement (C3) with pre-existing severe coronary artery disease and new vascular events in women

G. Széplaki, Z. Prohászka, J. Duba, Szabolcs Rugonfalvi-Kiss, I. Karádi, Márta Kókai, J. Krámer, G. Füst, Mónika Kleiber, László Romics, L. Varga

Research output: Article

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Abstract

Atherosclerosis is an inflammatory disease. The complement system plays an important role in the atherosclerotic process. However, lesser data is available on the possible role of C3 as a risk factor for atherosclerosis. Therefore, in a follow up study we determined C3 levels in 266 patients with pre-existing severe coronary artery disease (CAD) and compared their serum C3 concentrations with the cause of the disease. We investigated whether C3 levels predict the major complications of severe CAD during a 5-year long follow up period in patients, who have received an aorto-coronary bypass graft surgery. C3 concentrations were elevated in the patients with severe CAD compared to 182 healthy controls, and women had higher C3 concentrations than men. Pathological C3 levels (C3≥1.8 g/L) were able to predict major complications of atherosclerosis (death by cardiac events, new acute myocardial infarction, stroke, carotid surgery and peripheral arterial disease) that developed during the follow up period only in women (OR: 4.1, 95% C.I. 1.23-13.61, p = 0.0249) independent of other risk factors for atherosclerosis. Our data supports the assumption that high C3 indicates the progression of atherosclerosis as a special marker of chronic inflammation.

Original languageEnglish
Pages (from-to)383-389
Number of pages7
JournalAtherosclerosis
Volume177
Issue number2
DOIs
Publication statusPublished - dec. 2004

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Complement C3
Blood Vessels
Coronary Artery Disease
Atherosclerosis
Serum
Carotid Artery Diseases
Peripheral Arterial Disease
Stroke
Myocardial Infarction
Inflammation
Transplants

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Association of high serum concentration of the third component of complement (C3) with pre-existing severe coronary artery disease and new vascular events in women",
abstract = "Atherosclerosis is an inflammatory disease. The complement system plays an important role in the atherosclerotic process. However, lesser data is available on the possible role of C3 as a risk factor for atherosclerosis. Therefore, in a follow up study we determined C3 levels in 266 patients with pre-existing severe coronary artery disease (CAD) and compared their serum C3 concentrations with the cause of the disease. We investigated whether C3 levels predict the major complications of severe CAD during a 5-year long follow up period in patients, who have received an aorto-coronary bypass graft surgery. C3 concentrations were elevated in the patients with severe CAD compared to 182 healthy controls, and women had higher C3 concentrations than men. Pathological C3 levels (C3≥1.8 g/L) were able to predict major complications of atherosclerosis (death by cardiac events, new acute myocardial infarction, stroke, carotid surgery and peripheral arterial disease) that developed during the follow up period only in women (OR: 4.1, 95{\%} C.I. 1.23-13.61, p = 0.0249) independent of other risk factors for atherosclerosis. Our data supports the assumption that high C3 indicates the progression of atherosclerosis as a special marker of chronic inflammation.",
keywords = "Atherosclerosis, C3, Complement, Coronary artery disease, Inflammation, Myocardial infarction",
author = "G. Sz{\'e}plaki and Z. Proh{\'a}szka and J. Duba and Szabolcs Rugonfalvi-Kiss and I. Kar{\'a}di and M{\'a}rta K{\'o}kai and J. Kr{\'a}mer and G. F{\"u}st and M{\'o}nika Kleiber and L{\'a}szl{\'o} Romics and L. Varga",
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T1 - Association of high serum concentration of the third component of complement (C3) with pre-existing severe coronary artery disease and new vascular events in women

AU - Széplaki, G.

AU - Prohászka, Z.

AU - Duba, J.

AU - Rugonfalvi-Kiss, Szabolcs

AU - Karádi, I.

AU - Kókai, Márta

AU - Krámer, J.

AU - Füst, G.

AU - Kleiber, Mónika

AU - Romics, László

AU - Varga, L.

PY - 2004/12

Y1 - 2004/12

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AB - Atherosclerosis is an inflammatory disease. The complement system plays an important role in the atherosclerotic process. However, lesser data is available on the possible role of C3 as a risk factor for atherosclerosis. Therefore, in a follow up study we determined C3 levels in 266 patients with pre-existing severe coronary artery disease (CAD) and compared their serum C3 concentrations with the cause of the disease. We investigated whether C3 levels predict the major complications of severe CAD during a 5-year long follow up period in patients, who have received an aorto-coronary bypass graft surgery. C3 concentrations were elevated in the patients with severe CAD compared to 182 healthy controls, and women had higher C3 concentrations than men. Pathological C3 levels (C3≥1.8 g/L) were able to predict major complications of atherosclerosis (death by cardiac events, new acute myocardial infarction, stroke, carotid surgery and peripheral arterial disease) that developed during the follow up period only in women (OR: 4.1, 95% C.I. 1.23-13.61, p = 0.0249) independent of other risk factors for atherosclerosis. Our data supports the assumption that high C3 indicates the progression of atherosclerosis as a special marker of chronic inflammation.

KW - Atherosclerosis

KW - C3

KW - Complement

KW - Coronary artery disease

KW - Inflammation

KW - Myocardial infarction

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