Association Between Serum Lipid Profile and Obstructive Respiratory Events During REM and Non-REM Sleep

Andras Bikov, Zsofia Lazar, Peter Horvath, David Laszlo Tarnoki, Adam Domonkos Tarnoki, Luca Fesus, Marton Horvath, Martina Meszaros, Gyorgy Losonczy, Laszlo Kunos

Research output: Article

1 Citation (Scopus)

Abstract

Purpose: Obstructive sleep apnoea (OSA) represents a risk for dyslipidaemia. Obstructive respiratory events during rapid eye movement (REM) sleep are more strongly related to the development of hypertension and diabetes than in non-REM. However, the relationship between sleep phases and serum lipid profile is unclear. We aimed to analyse the relationship between obstructive respiratory events in REM and non-REM sleep as well as serum lipid profile. Methods: Polysomnography was performed in 94 adult subjects who did not take any lipid-modifying medications. Fasting venous blood sample was taken the following morning for total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, lipoprotein(a), apoprotein A1 (ApoA1) and for apoprotein B (ApoB) measurements. Lipid profiles were correlated with apnoea–hypopnoea index (AHI) during REM (AHIREM) and non-REM (AHINREM) stages in all subjects. In addition, lipid profiles were compared between REM-dependent OSA patients (AHIREM ≥ 5/h, but AHINREM < 5/h) and control subjects (both AHIREM and AHINREM < 5/h). Results: AHIREM correlated only with triglyceride concentrations (p = 0.04, Spearman’s rho, ρ = 0.21). In contrast, there was a significant association between AHINREM and triglyceride (p = 0.02, ρ = 0.23), ApoB (p = 0.03, ρ = 0.21), HDL-C (p < 0.01, ρ = − 0.32) as well as ApoA1 levels (p = 0.04, ρ = − 0.21). However, these correlations were not present after adjustment for BMI (all p > 0.05). There was no difference in the lipid profile of REM-dependent OSA subjects and healthy controls (p > 0.05). Conclusions: Altered serum lipid profile is equally associated with a disturbed REM and non-REM sleep in OSA. Obesity must be considered as a strong covariate when interpreting lipid data in sleep apnoea.

Original languageEnglish
Pages (from-to)443-450
Number of pages8
JournalLung
Volume197
Issue number4
DOIs
Publication statusPublished - aug. 15 2019

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Fingerprint Dive into the research topics of 'Association Between Serum Lipid Profile and Obstructive Respiratory Events During REM and Non-REM Sleep'. Together they form a unique fingerprint.

  • Cite this

    Bikov, A., Lazar, Z., Horvath, P., Tarnoki, D. L., Tarnoki, A. D., Fesus, L., Horvath, M., Meszaros, M., Losonczy, G., & Kunos, L. (2019). Association Between Serum Lipid Profile and Obstructive Respiratory Events During REM and Non-REM Sleep. Lung, 197(4), 443-450. https://doi.org/10.1007/s00408-019-00195-7