Application of alicyclic β-amino acids in peptide chemistry

Research output: Review article

250 Citations (Scopus)

Abstract

The self-organizing β-peptides have attracted considerable interest in the fields of foldamer chemistry and biochemistry. These compounds exhibit various stable secondary structure motifs that can be exploited to construct biologically active substances and nanostructured tertiary structures. The secondary structures can be controlled via the β-amino acid sequence, and cyclic β-amino acid residues play a crucial role in the design. The most important procedures for the preparation of cyclic β-amino acid monomers and peptides are discussed in this tutorial review. Besides the secondary structure design principles, the methods of folded structure detection are surveyed.

Original languageEnglish
Pages (from-to)323-334
Number of pages12
JournalChemical Society Reviews
Volume35
Issue number4
DOIs
Publication statusPublished - ápr. 3 2006

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ASJC Scopus subject areas

  • Chemistry(all)

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