Abstract

The polymorphism of apolipoprotein E (apoE) has been recognized as a genetic risk factor for different neurodegenerative disorders - as Alzheimer's dementia, vascular dementia, Lewy body dementia - with or without tau-protein related neuropathology. There are only a few data concerning the association of different apoE alleles with the relatively rare Pick's dementia. This fact gave us inspiration to study apoE allele frequency in Pick's dementia. In this study, 36 pathologically proven probands with Pick's dementia and 79 healthy control subjects were examined. The apoE epsilon 4 allele frequency was significantly higher (42%) in Pick's dementia as compared to the healthy control group (8%). These results indicate that apoE epsilon 4 allele is not a specific susceptibility factor for Alzheimer's dementia, and it could be present in other dementing disorders, like Pick's dementia.

Original languageHungarian
Pages (from-to)60-65
Number of pages6
JournalPsychiatria Hungarica : A Magyar Pszichiátriai Társaság tudományos folyóirata
Volume15
Issue number1
Publication statusPublished - 2000

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Apolipoproteins E
Dementia
Apolipoprotein E4
Gene Frequency
Alzheimer Disease
Alleles
Lewy Body Disease
tau Proteins
Vascular Dementia
Neurodegenerative Diseases
Healthy Volunteers
Control Groups

Keywords

  • Allele polymorphism
  • Apolipoprotein E
  • Pick's dementia
  • Tau-protein

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

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title = "Apolipoprotein e polimorfizmus Pick-demenciaban",
abstract = "The polymorphism of apolipoprotein E (apoE) has been recognized as a genetic risk factor for different neurodegenerative disorders - as Alzheimer's dementia, vascular dementia, Lewy body dementia - with or without tau-protein related neuropathology. There are only a few data concerning the association of different apoE alleles with the relatively rare Pick's dementia. This fact gave us inspiration to study apoE allele frequency in Pick's dementia. In this study, 36 pathologically proven probands with Pick's dementia and 79 healthy control subjects were examined. The apoE epsilon 4 allele frequency was significantly higher (42{\%}) in Pick's dementia as compared to the healthy control group (8{\%}). These results indicate that apoE epsilon 4 allele is not a specific susceptibility factor for Alzheimer's dementia, and it could be present in other dementing disorders, like Pick's dementia.",
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author = "A. Juh{\'a}sz and A. Riman{\'o}czy and J. K{\'a}lm{\'a}n and K. Majt{\'e}nyi and I. Rask{\'o} and Z. Janka",
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T1 - Apolipoprotein e polimorfizmus Pick-demenciaban

AU - Juhász, A.

AU - Rimanóczy, A.

AU - Kálmán, J.

AU - Majtényi, K.

AU - Raskó, I.

AU - Janka, Z.

PY - 2000

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N2 - The polymorphism of apolipoprotein E (apoE) has been recognized as a genetic risk factor for different neurodegenerative disorders - as Alzheimer's dementia, vascular dementia, Lewy body dementia - with or without tau-protein related neuropathology. There are only a few data concerning the association of different apoE alleles with the relatively rare Pick's dementia. This fact gave us inspiration to study apoE allele frequency in Pick's dementia. In this study, 36 pathologically proven probands with Pick's dementia and 79 healthy control subjects were examined. The apoE epsilon 4 allele frequency was significantly higher (42%) in Pick's dementia as compared to the healthy control group (8%). These results indicate that apoE epsilon 4 allele is not a specific susceptibility factor for Alzheimer's dementia, and it could be present in other dementing disorders, like Pick's dementia.

AB - The polymorphism of apolipoprotein E (apoE) has been recognized as a genetic risk factor for different neurodegenerative disorders - as Alzheimer's dementia, vascular dementia, Lewy body dementia - with or without tau-protein related neuropathology. There are only a few data concerning the association of different apoE alleles with the relatively rare Pick's dementia. This fact gave us inspiration to study apoE allele frequency in Pick's dementia. In this study, 36 pathologically proven probands with Pick's dementia and 79 healthy control subjects were examined. The apoE epsilon 4 allele frequency was significantly higher (42%) in Pick's dementia as compared to the healthy control group (8%). These results indicate that apoE epsilon 4 allele is not a specific susceptibility factor for Alzheimer's dementia, and it could be present in other dementing disorders, like Pick's dementia.

KW - Allele polymorphism

KW - Apolipoprotein E

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KW - Tau-protein

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