Apolipoprotein A5 gene IVS3+G476A allelic variant confers susceptibility for development of ischemic stroke

Research output: Article

39 Citations (Scopus)

Abstract

Background T-1131C, T1259C and IVS3+G476A are naturally occurring variants of the apolipoprotein A5 (APOA5) gene and their possible impact on the development of ischemic stroke was investigated in the present study. Methods and Results PCR-RFLP assays were used to determine the distributions of the AP0A5 alleles in small-vessel, large-vessel and mixed subgroups of 378 patients and in 131 stroke-free control subjects. Increased triglyceride levels were found in subjects carrying -1131C, 1259C, IVS3+476A alleles in all stroke groups and in the controls. The -1131C and IVS3+476A alleles, but not the T1259C variant, showed significant accumulation in all stroke subgroups. Logistic regression analysis adjusted for age, gender, body mass index, total cholesterol level, ischemic heart disease, hypertension, diabetes mellitus, smoking-and drinking habits revealed that the IVS3+476A allele represents independent susceptibility factor for stroke (odds ratio for small-vessel: 4.748; large-vessel: 3.905; mixed: 2.926; overall: 3.644 at 95% confidence interval; p

Original languageEnglish
Pages (from-to)1065-1070
Number of pages6
JournalCirculation Journal
Volume72
Issue number7
DOIs
Publication statusPublished - 2008

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Apolipoproteins
Stroke
Alleles
Genes
Restriction Fragment Length Polymorphisms
Drinking
Habits
Myocardial Ischemia
Diabetes Mellitus
Triglycerides
Body Mass Index
Logistic Models
Smoking
Odds Ratio
Cholesterol
Regression Analysis
Confidence Intervals
Hypertension
Polymerase Chain Reaction
Control Groups

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

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title = "Apolipoprotein A5 gene IVS3+G476A allelic variant confers susceptibility for development of ischemic stroke",
abstract = "Background T-1131C, T1259C and IVS3+G476A are naturally occurring variants of the apolipoprotein A5 (APOA5) gene and their possible impact on the development of ischemic stroke was investigated in the present study. Methods and Results PCR-RFLP assays were used to determine the distributions of the AP0A5 alleles in small-vessel, large-vessel and mixed subgroups of 378 patients and in 131 stroke-free control subjects. Increased triglyceride levels were found in subjects carrying -1131C, 1259C, IVS3+476A alleles in all stroke groups and in the controls. The -1131C and IVS3+476A alleles, but not the T1259C variant, showed significant accumulation in all stroke subgroups. Logistic regression analysis adjusted for age, gender, body mass index, total cholesterol level, ischemic heart disease, hypertension, diabetes mellitus, smoking-and drinking habits revealed that the IVS3+476A allele represents independent susceptibility factor for stroke (odds ratio for small-vessel: 4.748; large-vessel: 3.905; mixed: 2.926; overall: 3.644 at 95{\%} confidence interval; p",
keywords = "APOA5, Ischemic stroke, T1259C-IVS3+G476A, Triglycerides",
author = "Anita Maasz and Peter Kisfali and Luca Jaromi and Katalin Horvatovich and Zoltan Szolnoki and Veronika Csongei and Eniko Safrany and Csilla Sipeky and Ferenc Hadarits and Bela Melegh",
year = "2008",
doi = "10.1253/circj.72.1065",
language = "English",
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pages = "1065--1070",
journal = "Circulation Journal",
issn = "1346-9843",
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TY - JOUR

T1 - Apolipoprotein A5 gene IVS3+G476A allelic variant confers susceptibility for development of ischemic stroke

AU - Maasz, Anita

AU - Kisfali, Peter

AU - Jaromi, Luca

AU - Horvatovich, Katalin

AU - Szolnoki, Zoltan

AU - Csongei, Veronika

AU - Safrany, Eniko

AU - Sipeky, Csilla

AU - Hadarits, Ferenc

AU - Melegh, Bela

PY - 2008

Y1 - 2008

N2 - Background T-1131C, T1259C and IVS3+G476A are naturally occurring variants of the apolipoprotein A5 (APOA5) gene and their possible impact on the development of ischemic stroke was investigated in the present study. Methods and Results PCR-RFLP assays were used to determine the distributions of the AP0A5 alleles in small-vessel, large-vessel and mixed subgroups of 378 patients and in 131 stroke-free control subjects. Increased triglyceride levels were found in subjects carrying -1131C, 1259C, IVS3+476A alleles in all stroke groups and in the controls. The -1131C and IVS3+476A alleles, but not the T1259C variant, showed significant accumulation in all stroke subgroups. Logistic regression analysis adjusted for age, gender, body mass index, total cholesterol level, ischemic heart disease, hypertension, diabetes mellitus, smoking-and drinking habits revealed that the IVS3+476A allele represents independent susceptibility factor for stroke (odds ratio for small-vessel: 4.748; large-vessel: 3.905; mixed: 2.926; overall: 3.644 at 95% confidence interval; p

AB - Background T-1131C, T1259C and IVS3+G476A are naturally occurring variants of the apolipoprotein A5 (APOA5) gene and their possible impact on the development of ischemic stroke was investigated in the present study. Methods and Results PCR-RFLP assays were used to determine the distributions of the AP0A5 alleles in small-vessel, large-vessel and mixed subgroups of 378 patients and in 131 stroke-free control subjects. Increased triglyceride levels were found in subjects carrying -1131C, 1259C, IVS3+476A alleles in all stroke groups and in the controls. The -1131C and IVS3+476A alleles, but not the T1259C variant, showed significant accumulation in all stroke subgroups. Logistic regression analysis adjusted for age, gender, body mass index, total cholesterol level, ischemic heart disease, hypertension, diabetes mellitus, smoking-and drinking habits revealed that the IVS3+476A allele represents independent susceptibility factor for stroke (odds ratio for small-vessel: 4.748; large-vessel: 3.905; mixed: 2.926; overall: 3.644 at 95% confidence interval; p

KW - APOA5

KW - Ischemic stroke

KW - T1259C-IVS3+G476A

KW - Triglycerides

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