Antinociceptive effect induced by a combination of opioid and neurotensin moieties vs. their hybrid peptide [Ile9]PK20 in an acute pain treatment in rodents

Patrycja Kleczkowska, Emmanuel Hermans, Piotr Kosson, Agnieszka Kowalczyk, Anna Lesniak, Karolina Pawlik, Engin Bojnik, S. Benyhe, Barbara Nowicka, Magdalena Bujalska-Zadrozny, Aleksandra Misicka, Andrzej W. Lipkowski

Research output: Article

6 Citations (Scopus)

Abstract

Hybrid compounds are suggested to be a more effective remedy for treatment of various diseases than combination therapy, since the attenuation or total disappearance of side effects, typically induced by a single moiety, can be observed. This is of great importance, especially when we consider problems resulting from the use of opioid analgesics. However, although it seems that such compounds can be valuable therapeutic tools, the lack of conviction among the public as to the appropriateness of their use still remains; therefore patients are commonly treated with polypharmacy. Thus, in the presented paper we show a comparison of the antinociceptive effect between a novel opioid-neurotensin chimera called [Ile9]PK20 and a mixture of its structural elements, delivered intrathecally and systemically. Additionally, motor coordination was assessed in the rotarod test. The results clearly indicate that spinal administration of the examined compounds, resulted in a long-lasting, dose- and time-dependent antinociceptive effect. Although the mixture of both pharmacophores was found to be more active than [Ile9]PK20, motor impairments surfaced as a side effect. This in turn illustrates the advantageous use of hybrid structures over drug cocktails.

Original languageEnglish
Pages (from-to)172-180
Number of pages9
JournalBrain Research
Volume1648
DOIs
Publication statusPublished - okt. 1 2016

Fingerprint

Neurotensin
Acute Pain
Opioid Analgesics
Rodentia
Peptides
Rotarod Performance Test
Polypharmacy
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Developmental Biology
  • Clinical Neurology

Cite this

Antinociceptive effect induced by a combination of opioid and neurotensin moieties vs. their hybrid peptide [Ile9]PK20 in an acute pain treatment in rodents. / Kleczkowska, Patrycja; Hermans, Emmanuel; Kosson, Piotr; Kowalczyk, Agnieszka; Lesniak, Anna; Pawlik, Karolina; Bojnik, Engin; Benyhe, S.; Nowicka, Barbara; Bujalska-Zadrozny, Magdalena; Misicka, Aleksandra; Lipkowski, Andrzej W.

In: Brain Research, Vol. 1648, 01.10.2016, p. 172-180.

Research output: Article

Kleczkowska, P, Hermans, E, Kosson, P, Kowalczyk, A, Lesniak, A, Pawlik, K, Bojnik, E, Benyhe, S, Nowicka, B, Bujalska-Zadrozny, M, Misicka, A & Lipkowski, AW 2016, 'Antinociceptive effect induced by a combination of opioid and neurotensin moieties vs. their hybrid peptide [Ile9]PK20 in an acute pain treatment in rodents', Brain Research, vol. 1648, pp. 172-180. https://doi.org/10.1016/j.brainres.2016.07.039
Kleczkowska, Patrycja ; Hermans, Emmanuel ; Kosson, Piotr ; Kowalczyk, Agnieszka ; Lesniak, Anna ; Pawlik, Karolina ; Bojnik, Engin ; Benyhe, S. ; Nowicka, Barbara ; Bujalska-Zadrozny, Magdalena ; Misicka, Aleksandra ; Lipkowski, Andrzej W. / Antinociceptive effect induced by a combination of opioid and neurotensin moieties vs. their hybrid peptide [Ile9]PK20 in an acute pain treatment in rodents. In: Brain Research. 2016 ; Vol. 1648. pp. 172-180.
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