Antibiotics A21459 A and B, New inhibitors of bacterial protein synthesis II. Structure elucidation

P. Ferrari, K. Vékey, M. Galimberti, G. G. Gallo, E. Selva, L. F. Zerilli

Research output: Article

23 Citations (Scopus)

Abstract

The structures of the antibiotics, active against a few Gram-negative bacteria and Clostridium difficile, were determined on the basis of physicochemical analyses on the intact molecules and on the acid hydrolysate of A21459 A. FAB-MS and 1H and 13C NMR investigations identified the amino acid units and determined their sequence. Antibiotics A21459 A and B are homodetic cyclic peptides constituted by eight amino acid units. They are glycine, methoxytryptophan, tryptophan, cysteine, alanine, sarcosine, dehydroalanine, and α-aminobutyric acid for A21459 A (alanine for A21459 B). Cysteine and alanine condensed to form a thiazole moiety, according to the biosymthesis of thiazole containing antibiotics.

Original languageEnglish
Pages (from-to)150-154
Number of pages5
JournalJournal of Antibiotics
Volume49
Issue number2
DOIs
Publication statusPublished - febr. 1996

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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