Anti-granulocyte scintigraphy in early rheumatoid arthritis - Does it work?

Edit Horkay, Gyöngyvér Kincse, J. Varga, Lajos Szabados, Ildikó Garai, J. Gaál

Research output: Article

Abstract

Objective: To compare the performance of anti-granulocyte scintigraphy with those of widely used prognostic indices (such as DAS28, anti-CCP, early MRI imaging). Methods: Twenty-five patients with early arthritis were enrolled into the study. Following the review of clinical data and the evaluation of disease activity, we performed MRI imaging of the hands, anti-granulocyte scintigraphy, and determined anti-CCP positivity. The relationship between the changes of MRI scores and the above prognostic factors were analyzed statistically. Results: At baseline, values were as follows: DAS28 3.86±1.19, CRI 0.15±0.12, MRI erosions and synovitis scores 25.11±12.82 and 4.32±4.02 (respectively), the ratio of anti-CCP positivity was 7/12 (58%). After the follow-up period of 13.6±2.52 months, erosion and synovitis scores were 43.11±22.23, and 5.32±6.16, respectively (p=0,001 and p=0,015). The occurrence of new erosions was correlated with baseline erosion score (k=0.523, p=0.022) and anti-CCP positivity (p=0.021). The relationship between CRI and baseline synovitis score was strong (=0.518, p=0.023), whereas it was weak only between the former and baseline erosion score (=0.402, p=0.08). Conclusion: As shown by this study, potential markers for predicting subsequent destructiveness in early RA include MRI and anti-CCP testing, primarily. 99mTc labeled anti-granulocyte joint scintigraphy is appropriate for the objective and quantitative appraisal of disease activity.

Original languageEnglish
Pages (from-to)558-564
Number of pages7
JournalCentral European Journal of Medicine
Volume8
Issue number5
DOIs
Publication statusPublished - okt. 2013

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Synovitis
Granulocytes
Radionuclide Imaging
Rheumatoid Arthritis
Arthritis
Hand
Joints

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Anti-granulocyte scintigraphy in early rheumatoid arthritis - Does it work? / Horkay, Edit; Kincse, Gyöngyvér; Varga, J.; Szabados, Lajos; Garai, Ildikó; Gaál, J.

In: Central European Journal of Medicine, Vol. 8, No. 5, 10.2013, p. 558-564.

Research output: Article

Horkay, Edit ; Kincse, Gyöngyvér ; Varga, J. ; Szabados, Lajos ; Garai, Ildikó ; Gaál, J. / Anti-granulocyte scintigraphy in early rheumatoid arthritis - Does it work?. In: Central European Journal of Medicine. 2013 ; Vol. 8, No. 5. pp. 558-564.
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abstract = "Objective: To compare the performance of anti-granulocyte scintigraphy with those of widely used prognostic indices (such as DAS28, anti-CCP, early MRI imaging). Methods: Twenty-five patients with early arthritis were enrolled into the study. Following the review of clinical data and the evaluation of disease activity, we performed MRI imaging of the hands, anti-granulocyte scintigraphy, and determined anti-CCP positivity. The relationship between the changes of MRI scores and the above prognostic factors were analyzed statistically. Results: At baseline, values were as follows: DAS28 3.86±1.19, CRI 0.15±0.12, MRI erosions and synovitis scores 25.11±12.82 and 4.32±4.02 (respectively), the ratio of anti-CCP positivity was 7/12 (58{\%}). After the follow-up period of 13.6±2.52 months, erosion and synovitis scores were 43.11±22.23, and 5.32±6.16, respectively (p=0,001 and p=0,015). The occurrence of new erosions was correlated with baseline erosion score (k=0.523, p=0.022) and anti-CCP positivity (p=0.021). The relationship between CRI and baseline synovitis score was strong (=0.518, p=0.023), whereas it was weak only between the former and baseline erosion score (=0.402, p=0.08). Conclusion: As shown by this study, potential markers for predicting subsequent destructiveness in early RA include MRI and anti-CCP testing, primarily. 99mTc labeled anti-granulocyte joint scintigraphy is appropriate for the objective and quantitative appraisal of disease activity.",
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AU - Horkay, Edit

AU - Kincse, Gyöngyvér

AU - Varga, J.

AU - Szabados, Lajos

AU - Garai, Ildikó

AU - Gaál, J.

PY - 2013/10

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N2 - Objective: To compare the performance of anti-granulocyte scintigraphy with those of widely used prognostic indices (such as DAS28, anti-CCP, early MRI imaging). Methods: Twenty-five patients with early arthritis were enrolled into the study. Following the review of clinical data and the evaluation of disease activity, we performed MRI imaging of the hands, anti-granulocyte scintigraphy, and determined anti-CCP positivity. The relationship between the changes of MRI scores and the above prognostic factors were analyzed statistically. Results: At baseline, values were as follows: DAS28 3.86±1.19, CRI 0.15±0.12, MRI erosions and synovitis scores 25.11±12.82 and 4.32±4.02 (respectively), the ratio of anti-CCP positivity was 7/12 (58%). After the follow-up period of 13.6±2.52 months, erosion and synovitis scores were 43.11±22.23, and 5.32±6.16, respectively (p=0,001 and p=0,015). The occurrence of new erosions was correlated with baseline erosion score (k=0.523, p=0.022) and anti-CCP positivity (p=0.021). The relationship between CRI and baseline synovitis score was strong (=0.518, p=0.023), whereas it was weak only between the former and baseline erosion score (=0.402, p=0.08). Conclusion: As shown by this study, potential markers for predicting subsequent destructiveness in early RA include MRI and anti-CCP testing, primarily. 99mTc labeled anti-granulocyte joint scintigraphy is appropriate for the objective and quantitative appraisal of disease activity.

AB - Objective: To compare the performance of anti-granulocyte scintigraphy with those of widely used prognostic indices (such as DAS28, anti-CCP, early MRI imaging). Methods: Twenty-five patients with early arthritis were enrolled into the study. Following the review of clinical data and the evaluation of disease activity, we performed MRI imaging of the hands, anti-granulocyte scintigraphy, and determined anti-CCP positivity. The relationship between the changes of MRI scores and the above prognostic factors were analyzed statistically. Results: At baseline, values were as follows: DAS28 3.86±1.19, CRI 0.15±0.12, MRI erosions and synovitis scores 25.11±12.82 and 4.32±4.02 (respectively), the ratio of anti-CCP positivity was 7/12 (58%). After the follow-up period of 13.6±2.52 months, erosion and synovitis scores were 43.11±22.23, and 5.32±6.16, respectively (p=0,001 and p=0,015). The occurrence of new erosions was correlated with baseline erosion score (k=0.523, p=0.022) and anti-CCP positivity (p=0.021). The relationship between CRI and baseline synovitis score was strong (=0.518, p=0.023), whereas it was weak only between the former and baseline erosion score (=0.402, p=0.08). Conclusion: As shown by this study, potential markers for predicting subsequent destructiveness in early RA include MRI and anti-CCP testing, primarily. 99mTc labeled anti-granulocyte joint scintigraphy is appropriate for the objective and quantitative appraisal of disease activity.

KW - Anti-CCP positivity

KW - Anti-granulocyte scintigraphy

KW - Leukocyte accumulation

KW - MRI

KW - Prediction of erosiveness

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