Clotrimazole, a widely used imidazole-type antifungal agent and its cyclodextrin complexes were studied. Stoichiometries, structures and stability constants of the inclusion complexes with fourteen different cyclodextrin derivatives were characterized using NMR spectroscopy as primary technique. The cyclodextrin complexes were found to be of high stability (logK > 2). 2D ROESY NMR spectra revealed the formation of isomeric complexes with every cyclodextrin studied. The highest stability constant was observed with sulfobutylated β-CD, and interestingly enough the heptakis(2,3,6tri-O-methyl)-β-cyclodextrin showed the lowest stability.
ASJC Scopus subject areas
- Materials Science (miscellaneous)
- Surfaces, Coatings and Films
- Materials Chemistry