Objective: The goal of this study was to develop an improved 62Zn/62Cu generator based on cation exchange resin and remote preparation at high radioactivity scale for clinical use. Methods: A natural Cu target was irradiated with proton beam in the energy range of 30→19 MeV at a beam current of 10 μA for 1 h to obtain around 1.7 GBq of 62Zn. The 62Zn was isolated from the Cu target on an anion exchange column with more than 97% yield within 2.5 h from the EOB. The 62Zn/62Cu generator was prepared by loading the 62Zn2+ on a Sep-Pak plus CM cartridge. Results: The generator showed high elution efficiency (∼96%) using a small volume (ca. 3 ml) of a 200-mM glycine solution with a very low breakthrough of 62Zn (<0.1%). Conclusions: This 62Zn/62Cu generator has been proven to be highly useful as a source of 62Cu for the synthesis of 62Cu-labeled compounds. The clinical application of [62Cu]Cu-ATSM produced with this generator has been already approved by the Institutional Review Board at the National Institute of Radiological Sciences.
ASJC Scopus subject areas
- Molecular Medicine
- Radiology Nuclear Medicine and imaging
- Cancer Research