An environmentally friendly route for the synthesis of benzofurane derivatives using selective ring acylation of resorcinol

Sándor Békássy, B. Ágai, János Farkas, Eszter Gábor, Mária Ferenczi, François Figueras

Research output: Article

3 Citations (Scopus)

Abstract

The synthesis of 2,2-dimethyl-2,3-dihydro-benzofuran-6-ol, an important intermediate for benzofurane derivatives having pharmaceutical activity, is achieved by an environmentally friendly pathway. Whereas the current synthesis method, based on resorcinol dimethylether, uses or produces harmful, corrosive and dangerous reagents/materials, the procedure proposed here achieves 60% preparative yield for the selective direct ring acylation of resorcinol with isobutyryl chloride, using a solvent-free reaction catalysed by solid acids.

Original languageEnglish
Pages (from-to)219-223
Number of pages5
JournalCatalysis Letters
Volume118
Issue number3-4
DOIs
Publication statusPublished - okt. 2007

Fingerprint

acylation
Acylation
routes
Derivatives
Caustics
rings
synthesis
Drug products
reagents
Chlorides
chlorides
acids
Acids
Pharmaceutical Preparations
resorcinol
benzofuran

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Catalysis

Cite this

An environmentally friendly route for the synthesis of benzofurane derivatives using selective ring acylation of resorcinol. / Békássy, Sándor; Ágai, B.; Farkas, János; Gábor, Eszter; Ferenczi, Mária; Figueras, François.

In: Catalysis Letters, Vol. 118, No. 3-4, 10.2007, p. 219-223.

Research output: Article

Békássy, Sándor ; Ágai, B. ; Farkas, János ; Gábor, Eszter ; Ferenczi, Mária ; Figueras, François. / An environmentally friendly route for the synthesis of benzofurane derivatives using selective ring acylation of resorcinol. In: Catalysis Letters. 2007 ; Vol. 118, No. 3-4. pp. 219-223.
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