An efficient stereoselective total synthesis of (±)-trans-dihydronarciclasine

Gábor Varró, L. Hegedûs, András Simon, István Kádas

Research output: Article

7 Citations (Scopus)

Abstract

A short and efficient stereoselective total synthesis of (±)-trans-dihydronarciclasine (1), a highly potent naturally occurring antineoplastic agent, was developed from readily available vanillin (7). The key intermediate of this new synthesis was a butenone derivative (11), from which the target molecule could be obtained in 14, mostly stereoselective, reaction steps. Our total synthesis has provided an easy and, up to now, the least expensive access to the title alkaloid.

Original languageEnglish
JournalTetrahedron Letters
Volume57
Issue number14
DOIs
Publication statusPublished - ápr. 6 2016

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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