An easy access to tetra-o-alkylated calix[4]arenes of cone conformation

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26 Citations (Scopus)

Abstract

Fully O-alkylated calix[4]arenes have been synthesized by the alkylation of p-tertbutylcalix[4]arene and its 1,3-dialkylated derivatives in liquid-liquid phase-transfer catalytic process. 1H4 and 1H2R2 could effeciently be deprotonated by aqueous NaOH (50% w/w)-toluene system and alkylated with alkyl (aralkyl, allyl) halogens in good yields affording calix[4]arene tetraethers of cone conformation.

Original languageEnglish
Pages (from-to)7835-7840
Number of pages6
JournalTetrahedron
Volume51
Issue number28
DOIs
Publication statusPublished - júl. 10 1995

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Halogens
Alkylation
Toluene
Conformations
Cones
Liquids
Derivatives
calix(4)arene

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

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title = "An easy access to tetra-o-alkylated calix[4]arenes of cone conformation",
abstract = "Fully O-alkylated calix[4]arenes have been synthesized by the alkylation of p-tertbutylcalix[4]arene and its 1,3-dialkylated derivatives in liquid-liquid phase-transfer catalytic process. 1H4 and 1H2R2 could effeciently be deprotonated by aqueous NaOH (50{\%} w/w)-toluene system and alkylated with alkyl (aralkyl, allyl) halogens in good yields affording calix[4]arene tetraethers of cone conformation.",
author = "I. Bitter and A. Gr{\"u}n and B. {\'A}gai and L. Tőke",
year = "1995",
month = "7",
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doi = "10.1016/0040-4020(95)00401-S",
language = "English",
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pages = "7835--7840",
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T1 - An easy access to tetra-o-alkylated calix[4]arenes of cone conformation

AU - Bitter, I.

AU - Grün, A.

AU - Ágai, B.

AU - Tőke, L.

PY - 1995/7/10

Y1 - 1995/7/10

N2 - Fully O-alkylated calix[4]arenes have been synthesized by the alkylation of p-tertbutylcalix[4]arene and its 1,3-dialkylated derivatives in liquid-liquid phase-transfer catalytic process. 1H4 and 1H2R2 could effeciently be deprotonated by aqueous NaOH (50% w/w)-toluene system and alkylated with alkyl (aralkyl, allyl) halogens in good yields affording calix[4]arene tetraethers of cone conformation.

AB - Fully O-alkylated calix[4]arenes have been synthesized by the alkylation of p-tertbutylcalix[4]arene and its 1,3-dialkylated derivatives in liquid-liquid phase-transfer catalytic process. 1H4 and 1H2R2 could effeciently be deprotonated by aqueous NaOH (50% w/w)-toluene system and alkylated with alkyl (aralkyl, allyl) halogens in good yields affording calix[4]arene tetraethers of cone conformation.

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U2 - 10.1016/0040-4020(95)00401-S

DO - 10.1016/0040-4020(95)00401-S

M3 - Article

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VL - 51

SP - 7835

EP - 7840

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

IS - 28

ER -