M. Bely, A. Apathy

Research output: Review article

4 Citations (Scopus)


Current knowledge of amyloidosis is summarized from the pathologist's viewpoint. Different forms of amyloidosis are considered, e.g. 1. systemic generalized amyloidosis: secondary (reactive, AA), primary (immunocyte, plasma cell, B-cell dyscrasia, AL), senile, haemodialysis-associated, hereditary; 2. isolated (localized) amyloidosis: cerebral, dystrophic (age related, commonly called 'senile'), endocrine related, localized to tumors, and focal plasma cell (B-cell) dyscrasia related amyloidosis. Histochemical and immunohistochemical differential diagnosis of amyloidosis in surgical pathology is summarised. Secondary amyloid is sensitive to KMnO4 oxidation, and by 0.1% trypsin digestion the green birefringence in polarized light disappears, while primary, senile, and localized (isolated) amyloid is resistant. Performiat pretreatment is followed by pronounced congophilia. Secondary amyloid is sensitive to performiat pretreatment, while primary, senile, and localized (isolated) amyloid deposits are constantly positively birefringent.

Original languageHungarian
Pages (from-to)570-579
Number of pages10
JournalLege Artis Medicinae
Issue number9
Publication statusPublished - okt. 16 1997



  • Amyloidosis
  • Isolated (localized) amyloidosis
  • Systemic amyloidosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bely, M., & Apathy, A. (1997). AMYLOIDOSIS. Lege Artis Medicinae, 7(9), 570-579.