Current knowledge of amyloidosis is summarized from the pathologist's viewpoint. Different forms of amyloidosis are considered, e.g. 1. systemic generalized amyloidosis: secondary (reactive, AA), primary (immunocyte, plasma cell, B-cell dyscrasia, AL), senile, haemodialysis-associated, hereditary; 2. isolated (localized) amyloidosis: cerebral, dystrophic (age related, commonly called 'senile'), endocrine related, localized to tumors, and focal plasma cell (B-cell) dyscrasia related amyloidosis. Histochemical and immunohistochemical differential diagnosis of amyloidosis in surgical pathology is summarised. Secondary amyloid is sensitive to KMnO4 oxidation, and by 0.1% trypsin digestion the green birefringence in polarized light disappears, while primary, senile, and localized (isolated) amyloid is resistant. Performiat pretreatment is followed by pronounced congophilia. Secondary amyloid is sensitive to performiat pretreatment, while primary, senile, and localized (isolated) amyloid deposits are constantly positively birefringent.
|Number of pages||10|
|Journal||Lege Artis Medicinae|
|Publication status||Published - okt. 16 1997|
- Isolated (localized) amyloidosis
- Systemic amyloidosis
ASJC Scopus subject areas