Among commercially available fruit juices, pomegranate is the most effective inhibitor of PMS-trypsin amyloid-like fibrils formation

Phanindra Babu Kasi, M. Kotormán

Research output: Article

Abstract

The formation of amyloid fibrils is associated with many human illnesses, such as Alzheimer's, Huntington's, and Parkinson's diseases, amyotrophic lateral sclerosis, spongiform encephalitis, type 2 diabetes, and primary and secondary systemic amyloidosis. Nutrition contributes to the prevention of these diseases. The aim of our work was to look for commercially available fruit juices that can inhibit the formation of amyloid fibrils. Of the fruit juices that we examined, that of pomegranate was found to be the most effective inhibitory agent using turbidity measurements and Congo red binding assay. According to our experiments, pomegranate juice reduced the amount of PMS-trypsin amyloid-like fibrils to 3.7% at 5-fold dilution compared with the sample without pomegranate. The inhibitory effect of the pomegranate juice was concentration dependent.

Original languageEnglish
JournalNatural product communications
Volume14
Issue number6
DOIs
Publication statusPublished - jan. 1 2019

Fingerprint

Punicaceae
trypsin inhibitors
fruit juices
amyloid
Amyloid
juices
amyloidosis
Parkinson disease
Republic of the Congo
disease prevention
Alzheimer disease
encephalitis
human diseases
noninsulin-dependent diabetes mellitus
Congo Red
turbidity
trypsin
Huntington Disease
Amyotrophic Lateral Sclerosis
Amyloidosis

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine

Cite this

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abstract = "The formation of amyloid fibrils is associated with many human illnesses, such as Alzheimer's, Huntington's, and Parkinson's diseases, amyotrophic lateral sclerosis, spongiform encephalitis, type 2 diabetes, and primary and secondary systemic amyloidosis. Nutrition contributes to the prevention of these diseases. The aim of our work was to look for commercially available fruit juices that can inhibit the formation of amyloid fibrils. Of the fruit juices that we examined, that of pomegranate was found to be the most effective inhibitory agent using turbidity measurements and Congo red binding assay. According to our experiments, pomegranate juice reduced the amount of PMS-trypsin amyloid-like fibrils to 3.7{\%} at 5-fold dilution compared with the sample without pomegranate. The inhibitory effect of the pomegranate juice was concentration dependent.",
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