ADP receptors in platelet activation and aggregation

M. F. Hoylaerts, C. Oury, E. Tóth-Zsámboki, J. Vermylen

Research output: Article

18 Citations (Scopus)

Abstract

ADP plays a central role in platelet aggregation. Activation of platelets via ADP proceeds via three membrane receptor proteins, two of which are coupled to a G protein and the third one constituting an ion channel mediating rapid Ca2+-influx. Via Ca2+-mobilization, the Gq-coupled P2Y1 receptor acts in concert with the Gi-coupled P2T(AC) receptor, which functions by lowering intracellular cAMP levels. The importance of Ca2+-influx via the P2X1 ion channel remains to be elucidated.

Original languageEnglish
Pages (from-to)307-309
Number of pages3
JournalPlatelets
Volume11
Issue number6
Publication statusPublished - 2000

Fingerprint

Purinergic P2 Receptors
Platelet Activation
Ion Channels
Platelet Aggregation
Adenosine Diphosphate
Purinergic P2Y1 Receptors
GTP-Binding Proteins
Membrane Proteins

ASJC Scopus subject areas

  • Cell Biology
  • Hematology

Cite this

Hoylaerts, M. F., Oury, C., Tóth-Zsámboki, E., & Vermylen, J. (2000). ADP receptors in platelet activation and aggregation. Platelets, 11(6), 307-309.

ADP receptors in platelet activation and aggregation. / Hoylaerts, M. F.; Oury, C.; Tóth-Zsámboki, E.; Vermylen, J.

In: Platelets, Vol. 11, No. 6, 2000, p. 307-309.

Research output: Article

Hoylaerts, MF, Oury, C, Tóth-Zsámboki, E & Vermylen, J 2000, 'ADP receptors in platelet activation and aggregation', Platelets, vol. 11, no. 6, pp. 307-309.
Hoylaerts MF, Oury C, Tóth-Zsámboki E, Vermylen J. ADP receptors in platelet activation and aggregation. Platelets. 2000;11(6):307-309.
Hoylaerts, M. F. ; Oury, C. ; Tóth-Zsámboki, E. ; Vermylen, J. / ADP receptors in platelet activation and aggregation. In: Platelets. 2000 ; Vol. 11, No. 6. pp. 307-309.
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