Adherence to the EAU guidelines on Penile Cancer Treatment

European, multicentre, retrospective study

Maida Bada, Francesco Berardinelli, P. Nyírády, Judith Varga, Pasquale Ditonno, Michele Battaglia, Paolo Chiodini, Cosimo De Nunzio, Giorgia Tema, Alessandro Veccia, Alessandro Antonelli, Luca Cindolo, Claudio Simeone, Stefano Puliatti, Salvatore Micali, Luigi Schips

Research output: Article

Abstract

Purpose: The European Association of Urology (EAU) guidelines for penile cancer (PC) are exclusively based on retrospective studies and have low grades of recommendation. The aim of this study was to assess the adherence to guidelines by investigating the management strategies for primary tumours and inguinal lymph nodes. Methods: We retrospectively reviewed the clinical charts of 176 PC patients who underwent surgery in eight European centres from 2010 to 2016. The stage and grade were assessed according to the 2009 AJCC–UICC TNM classification system. To assess adherence rates, we compared theoretical and practical adherence to the EAU guidelines. Results: Overall, 176 patients were enrolled. Partial amputation was the most frequent surgical approach (39%). 53.7% of tumours were stage Tis-T1b and the remaining 46.3% were stage T2-T4. Palpable lymph nodes were detected in 30.1% of patients and 45.1% underwent lymphadenectomy (LY). A sizeable group of tumours (43.2%) were N0. For primary treatment, adherence to the EAU guidelines was good (66%). In non-adherent cases, reasons for discrepancy were patient’s choice (17%), surgeon’s preference (36%), and other causes (47%). For LY, the guideline adherence was 70%, with either patient’s or surgeon’s choice or other causes accounting for discrepancy in 28, 20, and 52% of non-adherent cases, respectively. Conclusion: Adherence to the EAU guidelines for PC was quite high across the eight European centres involved in the study. This notwithstanding, strategies for further improvement should be developed and evenly adopted.

Original languageEnglish
Pages (from-to)921-926
Number of pages6
JournalJournal of cancer research and clinical oncology
Volume145
Issue number4
DOIs
Publication statusPublished - ápr. 2 2019

Fingerprint

Penile Neoplasms
Urology
Multicenter Studies
Retrospective Studies
Guidelines
Guideline Adherence
Lymph Node Excision
Lymph Nodes
Therapeutics
Neoplasms
Groin
Neoplasm Staging
Amputation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Adherence to the EAU guidelines on Penile Cancer Treatment : European, multicentre, retrospective study. / Bada, Maida; Berardinelli, Francesco; Nyírády, P.; Varga, Judith; Ditonno, Pasquale; Battaglia, Michele; Chiodini, Paolo; De Nunzio, Cosimo; Tema, Giorgia; Veccia, Alessandro; Antonelli, Alessandro; Cindolo, Luca; Simeone, Claudio; Puliatti, Stefano; Micali, Salvatore; Schips, Luigi.

In: Journal of cancer research and clinical oncology, Vol. 145, No. 4, 02.04.2019, p. 921-926.

Research output: Article

Bada, M, Berardinelli, F, Nyírády, P, Varga, J, Ditonno, P, Battaglia, M, Chiodini, P, De Nunzio, C, Tema, G, Veccia, A, Antonelli, A, Cindolo, L, Simeone, C, Puliatti, S, Micali, S & Schips, L 2019, 'Adherence to the EAU guidelines on Penile Cancer Treatment: European, multicentre, retrospective study', Journal of cancer research and clinical oncology, vol. 145, no. 4, pp. 921-926. https://doi.org/10.1007/s00432-019-02864-9
Bada, Maida ; Berardinelli, Francesco ; Nyírády, P. ; Varga, Judith ; Ditonno, Pasquale ; Battaglia, Michele ; Chiodini, Paolo ; De Nunzio, Cosimo ; Tema, Giorgia ; Veccia, Alessandro ; Antonelli, Alessandro ; Cindolo, Luca ; Simeone, Claudio ; Puliatti, Stefano ; Micali, Salvatore ; Schips, Luigi. / Adherence to the EAU guidelines on Penile Cancer Treatment : European, multicentre, retrospective study. In: Journal of cancer research and clinical oncology. 2019 ; Vol. 145, No. 4. pp. 921-926.
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abstract = "Purpose: The European Association of Urology (EAU) guidelines for penile cancer (PC) are exclusively based on retrospective studies and have low grades of recommendation. The aim of this study was to assess the adherence to guidelines by investigating the management strategies for primary tumours and inguinal lymph nodes. Methods: We retrospectively reviewed the clinical charts of 176 PC patients who underwent surgery in eight European centres from 2010 to 2016. The stage and grade were assessed according to the 2009 AJCC–UICC TNM classification system. To assess adherence rates, we compared theoretical and practical adherence to the EAU guidelines. Results: Overall, 176 patients were enrolled. Partial amputation was the most frequent surgical approach (39{\%}). 53.7{\%} of tumours were stage Tis-T1b and the remaining 46.3{\%} were stage T2-T4. Palpable lymph nodes were detected in 30.1{\%} of patients and 45.1{\%} underwent lymphadenectomy (LY). A sizeable group of tumours (43.2{\%}) were N0. For primary treatment, adherence to the EAU guidelines was good (66{\%}). In non-adherent cases, reasons for discrepancy were patient’s choice (17{\%}), surgeon’s preference (36{\%}), and other causes (47{\%}). For LY, the guideline adherence was 70{\%}, with either patient’s or surgeon’s choice or other causes accounting for discrepancy in 28, 20, and 52{\%} of non-adherent cases, respectively. Conclusion: Adherence to the EAU guidelines for PC was quite high across the eight European centres involved in the study. This notwithstanding, strategies for further improvement should be developed and evenly adopted.",
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T1 - Adherence to the EAU guidelines on Penile Cancer Treatment

T2 - European, multicentre, retrospective study

AU - Bada, Maida

AU - Berardinelli, Francesco

AU - Nyírády, P.

AU - Varga, Judith

AU - Ditonno, Pasquale

AU - Battaglia, Michele

AU - Chiodini, Paolo

AU - De Nunzio, Cosimo

AU - Tema, Giorgia

AU - Veccia, Alessandro

AU - Antonelli, Alessandro

AU - Cindolo, Luca

AU - Simeone, Claudio

AU - Puliatti, Stefano

AU - Micali, Salvatore

AU - Schips, Luigi

PY - 2019/4/2

Y1 - 2019/4/2

N2 - Purpose: The European Association of Urology (EAU) guidelines for penile cancer (PC) are exclusively based on retrospective studies and have low grades of recommendation. The aim of this study was to assess the adherence to guidelines by investigating the management strategies for primary tumours and inguinal lymph nodes. Methods: We retrospectively reviewed the clinical charts of 176 PC patients who underwent surgery in eight European centres from 2010 to 2016. The stage and grade were assessed according to the 2009 AJCC–UICC TNM classification system. To assess adherence rates, we compared theoretical and practical adherence to the EAU guidelines. Results: Overall, 176 patients were enrolled. Partial amputation was the most frequent surgical approach (39%). 53.7% of tumours were stage Tis-T1b and the remaining 46.3% were stage T2-T4. Palpable lymph nodes were detected in 30.1% of patients and 45.1% underwent lymphadenectomy (LY). A sizeable group of tumours (43.2%) were N0. For primary treatment, adherence to the EAU guidelines was good (66%). In non-adherent cases, reasons for discrepancy were patient’s choice (17%), surgeon’s preference (36%), and other causes (47%). For LY, the guideline adherence was 70%, with either patient’s or surgeon’s choice or other causes accounting for discrepancy in 28, 20, and 52% of non-adherent cases, respectively. Conclusion: Adherence to the EAU guidelines for PC was quite high across the eight European centres involved in the study. This notwithstanding, strategies for further improvement should be developed and evenly adopted.

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KW - Adherence

KW - EAU guidelines

KW - Lymphadenectomy

KW - Partial amputation

KW - Penile cancer

KW - Total amputation

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