Adenosine metabolism, immunity and joint health

György Haskó, Luca Antonioli, Bruce N. Cronstein

Research output: Review article

14 Citations (Scopus)

Abstract

The purine nucleoside adenosine is a present in most body fluids where it regulates a wide variety of physiologic and pharmacologic processes. Adenosine mediates its effects through activating 4 G protein-coupled receptors expressed on the cell membrane: A1, A2A, A2B, and A3. The adenosine receptors are widely distributed in the body, and tissues with high expression include immune tissues, cartilage, bone, heart, and brain. Here we review the source and metabolism of adenosine and the role of adenosine in regulating immunity and cartilage biology.

Original languageEnglish
Pages (from-to)307-313
Number of pages7
JournalBiochemical Pharmacology
Volume151
DOIs
Publication statusPublished - máj. 2018

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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