Activity of the notch-signalling pathway in circulating human chronic lymphocytic leukaemia cells

M. Hajdu, A. Sebestyén, G. Barna, L. Reiniger, J. Jánosi, L. Sréter, J. Várkonyi, J. Demeter, L. Kópper

Research output: Article

13 Citations (Scopus)

Abstract

Dysregulation of the Notch-pathway has been implicated in the pathogenesis of chronic lymphocytic leukaemia (B-CLL). We characterized the mRNA expression of Notch pathway elements in circulating normal B- and B-CLL cells, and compared expression profiles with clinical and prognostic data. Similar expression profiles were found in normal B-cells and B-CLL cells, however, most B-CLL samples showed lower Hairy/Enhancer of Split-1 expression than normal B-cells, which suggests that the pathway is not over-activated in B-CLL. The expression of Notch-pathway genes did not correlate with other prognostic factors of B-CLL. The importance of Notch-signalling in CLL cells in lymphatic tissue microenvironments remains to be determined.

Original languageEnglish
Pages (from-to)271-275
Number of pages5
JournalScandinavian Journal of Immunology
Volume65
Issue number3
DOIs
Publication statusPublished - márc. 2007

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B-Cell Chronic Lymphocytic Leukemia
B-Lymphocytes
Lymphoid Tissue
Messenger RNA
Genes

ASJC Scopus subject areas

  • Immunology

Cite this

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title = "Activity of the notch-signalling pathway in circulating human chronic lymphocytic leukaemia cells",
abstract = "Dysregulation of the Notch-pathway has been implicated in the pathogenesis of chronic lymphocytic leukaemia (B-CLL). We characterized the mRNA expression of Notch pathway elements in circulating normal B- and B-CLL cells, and compared expression profiles with clinical and prognostic data. Similar expression profiles were found in normal B-cells and B-CLL cells, however, most B-CLL samples showed lower Hairy/Enhancer of Split-1 expression than normal B-cells, which suggests that the pathway is not over-activated in B-CLL. The expression of Notch-pathway genes did not correlate with other prognostic factors of B-CLL. The importance of Notch-signalling in CLL cells in lymphatic tissue microenvironments remains to be determined.",
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T1 - Activity of the notch-signalling pathway in circulating human chronic lymphocytic leukaemia cells

AU - Hajdu, M.

AU - Sebestyén, A.

AU - Barna, G.

AU - Reiniger, L.

AU - Jánosi, J.

AU - Sréter, L.

AU - Várkonyi, J.

AU - Demeter, J.

AU - Kópper, L.

PY - 2007/3

Y1 - 2007/3

N2 - Dysregulation of the Notch-pathway has been implicated in the pathogenesis of chronic lymphocytic leukaemia (B-CLL). We characterized the mRNA expression of Notch pathway elements in circulating normal B- and B-CLL cells, and compared expression profiles with clinical and prognostic data. Similar expression profiles were found in normal B-cells and B-CLL cells, however, most B-CLL samples showed lower Hairy/Enhancer of Split-1 expression than normal B-cells, which suggests that the pathway is not over-activated in B-CLL. The expression of Notch-pathway genes did not correlate with other prognostic factors of B-CLL. The importance of Notch-signalling in CLL cells in lymphatic tissue microenvironments remains to be determined.

AB - Dysregulation of the Notch-pathway has been implicated in the pathogenesis of chronic lymphocytic leukaemia (B-CLL). We characterized the mRNA expression of Notch pathway elements in circulating normal B- and B-CLL cells, and compared expression profiles with clinical and prognostic data. Similar expression profiles were found in normal B-cells and B-CLL cells, however, most B-CLL samples showed lower Hairy/Enhancer of Split-1 expression than normal B-cells, which suggests that the pathway is not over-activated in B-CLL. The expression of Notch-pathway genes did not correlate with other prognostic factors of B-CLL. The importance of Notch-signalling in CLL cells in lymphatic tissue microenvironments remains to be determined.

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JO - Scandinavian Journal of Immunology

JF - Scandinavian Journal of Immunology

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