Accelerated atherosclerosis in rheumatoid arthritis

Zoltán Szekanecz, György Kerekes, Henriett Dér, Zsuzsa Sándor, Zoltán Szabó, Anikó Végvári, Enikö Simkovics, Lilla Soós, Ágnes Szentpétery, Timea Besenyei, Gabriella Szücs, Sándor Szántó, László Tamási, Gyula Szegedi, Yehuda Shoenfeld, Pál Soltész

Research output: Conference contribution

90 Citations (Scopus)

Abstract

Cardiovascular disease is a leading cause of mortality in rheumatoid arthritis (RA). Endothelial dysfunction often precedes manifest atherosclerosis. Both traditional, Framingham risk factors and inflammation-associated factors are involved in RA-associated atherosclerosis. Among imaging techniques, the early determination of common carotid intima-media thickness (ccIMT), flow-mediated vasodilation (FMD), and nitroglycerine-mediated vasodilation (NMD) may be useful to determine atherosclerosis and endothelial dysfunction.We and others found increased ccIMT and impaired FMD in RA patients. Among immunological and metabolic laboratory markers, anticyclic citrullinated peptide (anti-CCP) antibodies, IgM rheumatoid factor, circulating immune complexes, pro-inflammatory cytokines including tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), Th0/Th1Tcells, homocysteine, dyslipidemia, decreased folate and vitamin B12 production, and impaired paraoxonase activity may all be involved in the development of vascular disease in RA. The early diagnosis of endothelial dysfunction and atherosclerosis, active immunosuppressive treatment, the use of drugs that control atherosclerosis, changes in sedentary lifestyle, and the close follow-up of RA patients may help to minimize cardiovascular risk in these individuals.

Original languageEnglish
Title of host publicationAutoimmunity, Part D
Subtitle of host publicationAutoimmune Disease, Annus Mirabilis
PublisherBlackwell Publishing Inc.
Pages349-358
Number of pages10
ISBN (Print)157331708X, 9781573317085
DOIs
Publication statusPublished - jún. 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1108
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Szekanecz, Z., Kerekes, G., Dér, H., Sándor, Z., Szabó, Z., Végvári, A., Simkovics, E., Soós, L., Szentpétery, Á., Besenyei, T., Szücs, G., Szántó, S., Tamási, L., Szegedi, G., Shoenfeld, Y., & Soltész, P. (2007). Accelerated atherosclerosis in rheumatoid arthritis. In Autoimmunity, Part D: Autoimmune Disease, Annus Mirabilis (pp. 349-358). (Annals of the New York Academy of Sciences; Vol. 1108). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1422.036