Abstract
Objectives: Systemic sclerosis (SSc) is a rare, chronic connective tissue disease involving multiple organ systems, including the eye. We evaluated the detailed clinical ocular manifestations of outpatients with SSc. Methods: Demographics, disease duration and subtype, nailfold capillaroscopy (NFC) patterns and laboratory parameters encompassing the autoantibody profile of 51 SSc patients were evaluated, and a general ocular examination was performed for each participant. Results: Twenty-nine patients (56.86%) had eyelid skin alterations, 26 (50.98%) had retinal abnormalities, 26 (50.98%) had cataracts, 8 (15.69%) had conjunctival changes, 7 (13.73%) had iris abnormalities, 33 (64.71%) suffered from dry eye disease (DED), and 11 (21.57%) suffered from glaucoma. Significant positive correlations were found between NFC data and both tear breakup time and Ocular Surface Disease Index test values. Conclusions: Eyelid skin abnormalities, DED and retinal abnormalities are among the most common SSc-related ocular involvements. Diverse ophthalmic findings are attributed to the heterogeneity of SSc.
| Original language | English |
|---|---|
| Journal | Ocular Immunology and Inflammation |
| DOIs | |
| Publication status | Accepted/In press - jan. 1 2019 |
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ASJC Scopus subject areas
- Immunology and Allergy
- Ophthalmology
Cite this
A Wide Spectrum of Ocular Manifestations Signify Patients with Systemic Sclerosis. / Szucs, Gabriella; Szekanecz, Zoltan; Aszalos, Zsuzsa; Gesztelyi, Rudolf; Zsuga, Judit; Szodoray, Peter; Kemeny-Beke, Adam.
In: Ocular Immunology and Inflammation, 01.01.2019.Research output: Article
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TY - JOUR
T1 - A Wide Spectrum of Ocular Manifestations Signify Patients with Systemic Sclerosis
AU - Szucs, Gabriella
AU - Szekanecz, Zoltan
AU - Aszalos, Zsuzsa
AU - Gesztelyi, Rudolf
AU - Zsuga, Judit
AU - Szodoray, Peter
AU - Kemeny-Beke, Adam
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Objectives: Systemic sclerosis (SSc) is a rare, chronic connective tissue disease involving multiple organ systems, including the eye. We evaluated the detailed clinical ocular manifestations of outpatients with SSc. Methods: Demographics, disease duration and subtype, nailfold capillaroscopy (NFC) patterns and laboratory parameters encompassing the autoantibody profile of 51 SSc patients were evaluated, and a general ocular examination was performed for each participant. Results: Twenty-nine patients (56.86%) had eyelid skin alterations, 26 (50.98%) had retinal abnormalities, 26 (50.98%) had cataracts, 8 (15.69%) had conjunctival changes, 7 (13.73%) had iris abnormalities, 33 (64.71%) suffered from dry eye disease (DED), and 11 (21.57%) suffered from glaucoma. Significant positive correlations were found between NFC data and both tear breakup time and Ocular Surface Disease Index test values. Conclusions: Eyelid skin abnormalities, DED and retinal abnormalities are among the most common SSc-related ocular involvements. Diverse ophthalmic findings are attributed to the heterogeneity of SSc.
AB - Objectives: Systemic sclerosis (SSc) is a rare, chronic connective tissue disease involving multiple organ systems, including the eye. We evaluated the detailed clinical ocular manifestations of outpatients with SSc. Methods: Demographics, disease duration and subtype, nailfold capillaroscopy (NFC) patterns and laboratory parameters encompassing the autoantibody profile of 51 SSc patients were evaluated, and a general ocular examination was performed for each participant. Results: Twenty-nine patients (56.86%) had eyelid skin alterations, 26 (50.98%) had retinal abnormalities, 26 (50.98%) had cataracts, 8 (15.69%) had conjunctival changes, 7 (13.73%) had iris abnormalities, 33 (64.71%) suffered from dry eye disease (DED), and 11 (21.57%) suffered from glaucoma. Significant positive correlations were found between NFC data and both tear breakup time and Ocular Surface Disease Index test values. Conclusions: Eyelid skin abnormalities, DED and retinal abnormalities are among the most common SSc-related ocular involvements. Diverse ophthalmic findings are attributed to the heterogeneity of SSc.
KW - Dry eye disease
KW - nailfold capillaroscopy
KW - ocular findings
KW - ocular manifestations
KW - pathogenesis
KW - scleroderma
KW - systemic sclerosis
UR - http://www.scopus.com/inward/record.url?scp=85074039500&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85074039500&partnerID=8YFLogxK
U2 - 10.1080/09273948.2019.1657467
DO - 10.1080/09273948.2019.1657467
M3 - Article
C2 - 31577461
AN - SCOPUS:85074039500
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
SN - 0927-3948
ER -