A Wide Spectrum of Ocular Manifestations Signify Patients with Systemic Sclerosis

Gabriella Szucs, Zoltan Szekanecz, Zsuzsa Aszalos, Rudolf Gesztelyi, Judit Zsuga, Peter Szodoray, Adam Kemeny-Beke

Research output: Article

Abstract

Objectives: Systemic sclerosis (SSc) is a rare, chronic connective tissue disease involving multiple organ systems, including the eye. We evaluated the detailed clinical ocular manifestations of outpatients with SSc. Methods: Demographics, disease duration and subtype, nailfold capillaroscopy (NFC) patterns and laboratory parameters encompassing the autoantibody profile of 51 SSc patients were evaluated, and a general ocular examination was performed for each participant. Results: Twenty-nine patients (56.86%) had eyelid skin alterations, 26 (50.98%) had retinal abnormalities, 26 (50.98%) had cataracts, 8 (15.69%) had conjunctival changes, 7 (13.73%) had iris abnormalities, 33 (64.71%) suffered from dry eye disease (DED), and 11 (21.57%) suffered from glaucoma. Significant positive correlations were found between NFC data and both tear breakup time and Ocular Surface Disease Index test values. Conclusions: Eyelid skin abnormalities, DED and retinal abnormalities are among the most common SSc-related ocular involvements. Diverse ophthalmic findings are attributed to the heterogeneity of SSc.

Original languageEnglish
JournalOcular Immunology and Inflammation
DOIs
Publication statusAccepted/In press - jan. 1 2019

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Eye Manifestations
Systemic Scleroderma
Eye Diseases
Microscopic Angioscopy
Eyelids
Skin Abnormalities
Connective Tissue Diseases
Iris
Tears
Glaucoma
Autoantibodies
Cataract
Outpatients
Demography
Skin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

Cite this

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title = "A Wide Spectrum of Ocular Manifestations Signify Patients with Systemic Sclerosis",
abstract = "Objectives: Systemic sclerosis (SSc) is a rare, chronic connective tissue disease involving multiple organ systems, including the eye. We evaluated the detailed clinical ocular manifestations of outpatients with SSc. Methods: Demographics, disease duration and subtype, nailfold capillaroscopy (NFC) patterns and laboratory parameters encompassing the autoantibody profile of 51 SSc patients were evaluated, and a general ocular examination was performed for each participant. Results: Twenty-nine patients (56.86{\%}) had eyelid skin alterations, 26 (50.98{\%}) had retinal abnormalities, 26 (50.98{\%}) had cataracts, 8 (15.69{\%}) had conjunctival changes, 7 (13.73{\%}) had iris abnormalities, 33 (64.71{\%}) suffered from dry eye disease (DED), and 11 (21.57{\%}) suffered from glaucoma. Significant positive correlations were found between NFC data and both tear breakup time and Ocular Surface Disease Index test values. Conclusions: Eyelid skin abnormalities, DED and retinal abnormalities are among the most common SSc-related ocular involvements. Diverse ophthalmic findings are attributed to the heterogeneity of SSc.",
keywords = "Dry eye disease, nailfold capillaroscopy, ocular findings, ocular manifestations, pathogenesis, scleroderma, systemic sclerosis",
author = "Gabriella Szucs and Zoltan Szekanecz and Zsuzsa Aszalos and Rudolf Gesztelyi and Judit Zsuga and Peter Szodoray and Adam Kemeny-Beke",
year = "2019",
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language = "English",
journal = "Ocular Immunology and Inflammation",
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AU - Szucs, Gabriella

AU - Szekanecz, Zoltan

AU - Aszalos, Zsuzsa

AU - Gesztelyi, Rudolf

AU - Zsuga, Judit

AU - Szodoray, Peter

AU - Kemeny-Beke, Adam

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N2 - Objectives: Systemic sclerosis (SSc) is a rare, chronic connective tissue disease involving multiple organ systems, including the eye. We evaluated the detailed clinical ocular manifestations of outpatients with SSc. Methods: Demographics, disease duration and subtype, nailfold capillaroscopy (NFC) patterns and laboratory parameters encompassing the autoantibody profile of 51 SSc patients were evaluated, and a general ocular examination was performed for each participant. Results: Twenty-nine patients (56.86%) had eyelid skin alterations, 26 (50.98%) had retinal abnormalities, 26 (50.98%) had cataracts, 8 (15.69%) had conjunctival changes, 7 (13.73%) had iris abnormalities, 33 (64.71%) suffered from dry eye disease (DED), and 11 (21.57%) suffered from glaucoma. Significant positive correlations were found between NFC data and both tear breakup time and Ocular Surface Disease Index test values. Conclusions: Eyelid skin abnormalities, DED and retinal abnormalities are among the most common SSc-related ocular involvements. Diverse ophthalmic findings are attributed to the heterogeneity of SSc.

AB - Objectives: Systemic sclerosis (SSc) is a rare, chronic connective tissue disease involving multiple organ systems, including the eye. We evaluated the detailed clinical ocular manifestations of outpatients with SSc. Methods: Demographics, disease duration and subtype, nailfold capillaroscopy (NFC) patterns and laboratory parameters encompassing the autoantibody profile of 51 SSc patients were evaluated, and a general ocular examination was performed for each participant. Results: Twenty-nine patients (56.86%) had eyelid skin alterations, 26 (50.98%) had retinal abnormalities, 26 (50.98%) had cataracts, 8 (15.69%) had conjunctival changes, 7 (13.73%) had iris abnormalities, 33 (64.71%) suffered from dry eye disease (DED), and 11 (21.57%) suffered from glaucoma. Significant positive correlations were found between NFC data and both tear breakup time and Ocular Surface Disease Index test values. Conclusions: Eyelid skin abnormalities, DED and retinal abnormalities are among the most common SSc-related ocular involvements. Diverse ophthalmic findings are attributed to the heterogeneity of SSc.

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KW - pathogenesis

KW - scleroderma

KW - systemic sclerosis

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