A TR(I)P to pruritus research: Role of TRPV3 in inflammation and itch

Martin Steinhoff, Tamás Bíró

Research output: Comment/debate

48 Citations (Scopus)

Abstract

Pruritus in eczema and other inflammatory skin diseases is an unsolved problem. Recent findings strongly indicate that histamine is not the only mediator of pruritus. Subtypes of the transient receptor potential (TRP) ion channel superfamily are expressed by sensory nerves, keratinocytes, and certain leukocytes. Temperature, pH changes, and certain toxins activate TRPs. New evidence indicates that the vanilloid type 3 (TRPV3) channel is crucially involved in pruritic dermatitis, making it a good candidate for future therapy in skin inflammation and pruritus.

Original languageEnglish
Pages (from-to)531-535
Number of pages5
JournalJournal of Investigative Dermatology
Volume129
Issue number3
DOIs
Publication statusPublished - márc. 2009

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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